Nagi's 4th Lecture BLOOD Flashcards
What is the cause of the pernicious anemia
It is autoimmune disease that destroy the parietal cells that produce HCL and intrinsic factor so no B12 absorption
What is the kind of the anemia that caused by pernicious anemia
Macrocyctic Normia
What is the polycythemia
Increase if the RBCs
What are the types of polycythemia and what are their causes
Primary (polycythemia vera)
RBCs cancer
Secondly
Increase RBCs due to being in hypoxia for high attitude
What is the normal count of the platelets
150,000-450,000
What is the life spam of the platelets
8 days
What are thr components of the platelets plasma membrane
Glycoproteinlayer to adhesion with the collagen
Phosphatelipids:
Platelets factor 3
Arachidonic acid
What are the components of the platelets cytoplasm
Contracting proteins Prost glandins enzymes Glycogen as energy Granules: Dense (serotonin,ca,ADP) NON DENSE(factor 13,platelets drivate growth hormone,platelets activating factor )
What are prostaglandins
Active lipids act like hormones
What is the use of the arachidonic acid in the platelets
The prostaglandin enzymes turn it into prostaglandins
What are the steps of vasoconstriction in the pin brick
واحد تنين تلاتك و تلاتة فيها تلاتة Nerve reflex by pain From muscle by trama From the platelets Serotonin ADP Thromboxanes A2
What is the source of the thromboxase A2 and its function
From platelets and its is vc platelets aggregation
What is the source of the prostacyclin and its function
Is from endothelial cells
And its function is VD and prevention platelets aggregation
What is the effect of a small dose of aspirin on the thromboxase A2 and on the prostacyclin
It inhibits both of them but the prostacyclin get rid of the effect faster due to the big source and the total effect become prevent clots
What stimuli the externic pathway of coagulation
Tissue thrombo plastin
