myocarditis Flashcards

1
Q

what is it

A

acute inflammation of the myocardium

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2
Q

causes

A
  • idiopathic
  • infective
  • toxic
  • autoimune
  • alcohol
  • hydrocarbons
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3
Q

what are the infective causes

A
  • adenovirus
  • HIV
  • polio
  • parasites
  • bacterial (streptococcus, diphtheria)
  • lyme disease
  • fungal
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4
Q

what are the toxic causes

A
  • drugs
  • penicillin
  • radiation
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5
Q

what are the autoimmune causes

A
  • giant cell myocarditis

- autoimmune form

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6
Q

what is the most common cause in the west

A

Coxsackie or adenoviral infection

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7
Q

what is Chagas’ disease due to

A

trypansoma cruzi

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8
Q

what is the pathology of the acute phase

A

heart is flabby with focal haemorrhages

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9
Q

what is the pathology of chronic phase

A

heart is enlarged and hypertrophied

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10
Q

what is seen histologically

A

inflammatory infiltrate is present

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11
Q

what predominates with viral causes

A

lymphocytes

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12
Q

what predominates with bacterial causes

A

polymorphonuclear

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13
Q

what predominates with allergic and hypersensitivity causes

A

eosinophils

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14
Q

symptoms

A
  • asymptomatic
  • fatigue
  • palpitations
  • chest pain
  • dyspnoea
  • fulminant congestive cardiac failure
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15
Q

physical examination

A
  • soft heart sounds
  • prominent third sound
  • tachycardia
  • pericardial friction rub may be heard
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16
Q

what investigations are don e

A
  • CXR
  • ECG
  • cardiac enzymes
  • viral antibody titres
  • endomyocardial biopsy
  • viral RNA
17
Q

what is seen on CXR

A

cardiac enlargement

18
Q

what is seen on ECG

A
  • ST and T wave abnormalities
  • arrhythmias
  • heart block
  • lyme disease
  • chugs disease
19
Q

what are the cardiac enzymes

A

elevated

20
Q

what can biopsy show

A

acute inflammation

21
Q

what is the viral RNA

A

they PCR it

22
Q

what is the mainstay of treatment

A

supportive with heart failure medications

23
Q

what is further therapy

A

antibiotics and steroids

24
Q

what is treatment for acute phase

A
  • bed rest is common

- avoid athletic activities for 6 months

25
Q

what is used to treat heart failure

A
  • diuretics
  • ACE inhibitors / ARB
  • beta blocker
    or
  • spironolactone
26
Q

when should antibiotics be administered

A

immediately

27
Q

what is contraindicated in acute phase

A

NSAIDs

28
Q

what helps resolve left ventricular dysfunction

A

IV immunoglobulin

29
Q

what is giant cell myocarditis characterised by

A

presence of multinucleate giant cells within the myocardium

30
Q

what is the cause of giant cell myocarditis

A

associated with sarcoidosis, thymomas and autoimmune disease

31
Q

what is the cause of chagas’ disease

A

trypanosoma cruzi