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Year 2: Renal > Myeloma + Amyloidosis > Flashcards

Myeloma + Amyloidosis Flashcards

1
Q

Cancer of what

A

Plasma cells of the bone marrow

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2
Q

Protein produced by myeloma that causes kidney problems

A

Paraprotein

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3
Q

Symptoms

A

Bone pain
Weakness
Fatigue
Weight Loss

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4
Q

Signs

A 
Anaemia
Hypercalcaemia 
Renal failure
Amyloidosis
Recurrent infections
ROLEAUX FORMATION (stacks of RBCs)
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5
Q

Diagnosis

A

ESR/PV
FBC
MSU: monoclonal light chains (bence jones proteins)

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6
Q

what is amyloidosis

A

Deposition of insoluble amyloid fibrils in organs

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7
Q

Histology of amyloidosis

A

Positive congo red staining

Apple-green birefringence under polarised light

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8
Q

Symptoms of amyloidosis

A

Fatigue
Weight loss
Easy bruising
Peripheral oedema

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9
Q

Antibody in amyloidosis

A

Howell-jelly antibodies

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10
Q

Diagnosis

A

Urinalysis- bence jones proteins
Howell-jelly antibodies
USS shows large kidneys

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Year 2: Renal (25 decks)

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