Diabetic Kidney Disease Flashcards
1
Q
How is GFR affected in the early stages
A
INCREASED GFR due to hyper filtration
2
Q
Histological changes
A
Thickening of glomerular basement membrane, mesangial expansion, podocyte dysfunction, inflammation, glomerulosclerosis
3
Q
What are the nodules formed called
A
Kimmelstiel-Wilson lesions
4
Q
What urine abnormality is seen
A
proteinuria
5
Q
How is the likely hood of complications monitored
A
Proteinuria
the worse the proteinuria, the worse the disease
6
Q
Treatment
A
Tight glycemic control (HbA1C <7)
ACEI/ARB
Statin
7
Q
what is used to screen all patients annually
A
albumin: creatinine ratio (ACR)
- Early morning specimen
