Mycobacterial Infections

Question 0

It makes the bacteria acid-fastt

Answer 0

Mycolic acid

Question 1

Transmission of Mycobacterium TB

Answer 1

Aerosol

Question 2

Ingestion of __ may lead to GI TB

Answer 2

Sputum

Question 3

How is M.bovis transmitted?

Answer 3

Unpasteurized milk

Question 4

Control of T-cells to bacteria may lead to __ and __

Answer 4

Caseating granulomas

Cavitation

Question 5

Not part of primary TB
A. M.tuberculosis enters macrophages by pinocytosis (c/o several receptors of mediators)
B. Replication blocks formation of phagolysosome
C. Bacteremia with seeding of multip sites

Answer 5

A

phagocytosis dapat

Question 6

What do macrophages secrete to mount a Tcell response?

Answer 6

IL-12

Question 7

Release of interferon gamma leads to expression of this inducible enzyme

Answer 7

Nitric oxide synthase

Question 8

IDENTIFY
1-1.5 cm area of gray-white inflammation with consolidation at the lower area of the upper lobe, or at the upper area of the lower lobe, near the pleura

Self-limiting like lymphadenopathy

Answer 8

Ghon focus

Question 9

Combination of parenchymal lung lesion and nodal (hilar lymph nodes) involvement

IDENTIFY

Answer 9

Ghon complex

Question 10

radiologically detectable calcification following fibrosis

IDENTIFY

Answer 10

Ranke’s Complex

Question 11

A.Occurs in the host who is immune to M. Tuberculosis
B.Most commonly stems from reactivation of a latent infection
C.defensive reaction –> ⬇️ tissue necrosis
D.Classically involves the apex of the upper lobes of one or both lungs
FALSE ABOUT SECONDARY TB

Answer 11

C

⬆️ DAPAT

Question 12

False about progressive TB
A)May ensue in older adults and immunosuppressed people
B)Resembles acute bacterial pneumonia
C)Upper and middle lobe consolidation D)Pleural effusion

Answer 12

C

Lower dapat

Question 13

spots @ prog TB due to the infection that has spread via blood (hematogenous spread)

Answer 13

Miliary TB

Question 14

TB of vertebrae is aka __

Answer 14

Pott’s Disease

Question 15

Gold standard of TB diag

Answer 15

AFB Culture

Question 16

TB Media : __

Answer 16

Lowenstein-Jensen Agar

Question 17

BCG means

Answer 17

Bacillus Calmette-Guerin

Question 18

Hallmark of Mycobacterium avium complex

Answer 18

Abundant AFB within macrophages

Question 19

For MAC:Dissemination through __ dep on severity of immune def

Answer 19

Mononuclear Phagocyte System

Question 20

False abt M.leprae
A.Acid fast, Obligate, Intracellular organism
B.Poorly cultured
C.Usually targets the muscle and peripheral nerves
D.Slow painful (less) death

Answer 20

C

SKIN DAPAT

Question 21

M.leprae - There is no certain optimal temperature needed for its growth.

T OR F

Answer 21

F

Question 22

False about M.lepeae
A. human respiratory secretions or soil are likely origins
B. Replicates primarily in relatively warm tissues of the skin and extremities
C.Virulence is based on properties of its cell wall – no toxins

Answer 22

B

Cool dapat

Question 23

False about tuberculoid leprosy
A.Well demarcated skin and nerve lesions 
B.Assymetric 
C.Granulomas are formed
D.Multibacillary

Answer 23

D

Pauci dapat

Question 24

In lepromatous leprosy, coalescent lesions in the face are called __

Answer 24

leonine facies

Question 25

Where does Hypergammmaglobulinemia occur?
A.lepromatous
B.tuberculoid
C.both

Answer 25

A

normal serum Ig @ tuberculoid