Enteropathogenic Bacterial Infections Flashcards
Vibrio cholera causes pandemics via A.contaminated drinking water B.fecal contamination C.skin penetration D.all of the above
A
Cholera toxin causes passage of stool with the ff characteristics except A. rice watery look B. rotten fish door C. bloody accompaniment D. none of the above
C
Cholera toxin has __ subunits
5
Which subunit/s cause adhesion?
4 beta subunit
Which subunit/s cause signal transduction?
1 alpha subunit
End effect: affects __ –> effusion of chloride ions from intracellular compartment to extracellular compartment –> water goes with the ions (loss of water)
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
Cholera is self limiting disease, all that has to be done is ___
fluid replacement
false about Campylobacter jejuni
A.mode of transmission: skin penetration
B.Usually seen in uncooked chicken, unpasteurized milk and contaminated water
C.Causes a form of nonspecific watery diarrhoea
D.diagnosis is through stool exam
A
false about histopathology (C.jejuni) A.Mucosal and intraepithelial neutrophils B.RBCs in crypts C.both are false D.both are true
B
WBC dapat
T or F
Shigella is a gram (-), unencapsulated, motile bacteria that can resist acidic environment of stomach
F
non-motile dapat
False about Shigellosis A)Potent and infective B)Initial dysentery but not mild self-limited diarrhea C)causes ulceration and haemorrhage D)none of the above
B
both are caused
Shiga toxin inhibits __ synthesis leading to cell death
eukaryotic protein
T or F
Antidiarrheal medications are contraindicated because they can prolong symptoms and delay Shigella clearance
T
Which is false?
a. There is no vaccine for typhoidal cases of diarrhoea
b. Humans are the sole reservoir
c. both are false
d. both are true
A
In S.enterica infection, there is hyperplasia of Peyer’s patches. This may mimic __
appendicitis
small erythematous maculopapular lesions on chest and abdomen found in patients with S.enterica
Rose spots
False about Yersinia
A.involves ileum, appendix, and right colon
B.can mimic acute appendicitis
C.symptoms:arthralgia and erythema nodosum
D.virulence enhanced by calcium
D
Iron dapat
T or F
Salmonella enteritidis causes typhoid
F
strain of E.coli which has heat-labile and heat-stable toxins
Enterotoxigenic
Heat-stable toxin of ETEC binds to ___ to increase cGMP
guanylate cyclase
Which has this virulence: attaching/effacing mechanism --> microvilli A. ETEC B. EPEC C. EIEC D. all of the above
B
Cows are natural reservoir for A. EIEC B. EPEC C. ETEC D. EHEC
D
Official name of EHEC
E. coli O157:H7
Type of E.coli with Shiga-like toxin A. EHEC B. EIEC C. ETEC D. all of the above
A
Similar to Shigella biologically, no toxins in virulence A. EHEC B. EIEC C. EAEC D. all of the above
B
Which has dispersin? A. EHEC B. EIEC C. EAEC D. all of the above
C
What does dispersin do?
neutralizes negative surface chargeof LPS
Toxins –> ribosylation of ___ –>disruption of the epithelial cytoskeleton, tight junction barrier loss, cytokine release, and apoptosis
This is the pathogenesis of C.difficile. Fill in the blanks
small GTPases(Rho)
identify
Made up of anadherent layers of inflammatory cells and debris at sites of colonic mucosal injury
pseudomembranes
In pseudomembranous colitis, there are distended crypts due to ___
mucopurulent exudate
causative agent of Whipple disease
Tropheryma whippeli
morphology of Tropheryma whippeli
A. Gram (+) actinomycete
B. Gram (-) actinomycete
C. acid fast actinomycete
A
post-morten exam manic of Whipple disease
presence of foamy macrophages and many argyrophilic rods in lymph nodes
false about Tropheryma whippeli A.Periodic Acid-Schiff (PAS)-positive B.acid fast positive C.Gram positive D. none of the above
B
Areas of bacteria-laden macrophages accumulation include all except: A.Mesenteric lymph vessels B.Synovial membranes of affected joints C.Cardiac valves D.Brain
A
nodes, not vessels
