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PH 122 > Enteropathogenic Bacterial Infections > Flashcards

Enteropathogenic Bacterial Infections Flashcards

1
Q 
Vibrio cholera causes pandemics via 
A.contaminated drinking water
B.fecal contamination
C.skin penetration
D.all of the above
A

A

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2
Q 
Cholera toxin causes passage of stool with the ff characteristics except
A. rice watery look
B. rotten fish door
C. bloody accompaniment
D. none of the above
A

C

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3
Q

Cholera toxin has __ subunits

A

5

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4
Q

Which subunit/s cause adhesion?

A

4 beta subunit

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5
Q

Which subunit/s cause signal transduction?

A

1 alpha subunit

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6
Q

End effect: affects __ –> effusion of chloride ions from intracellular compartment to extracellular compartment –> water goes with the ions (loss of water)

A

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

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7
Q

Cholera is self limiting disease, all that has to be done is ___

A

fluid replacement

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8
Q

false about Campylobacter jejuni
A.mode of transmission: skin penetration
B.Usually seen in uncooked chicken, unpasteurized milk and contaminated water
C.Causes a form of nonspecific watery diarrhoea
D.diagnosis is through stool exam

A

A

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9
Q 
false about histopathology (C.jejuni)
A.Mucosal and intraepithelial neutrophils
B.RBCs in crypts
C.both are false
D.both are true
A

B

WBC dapat

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10
Q

T or F

Shigella is a gram (-), unencapsulated, motile bacteria that can resist acidic environment of stomach

A

F

non-motile dapat

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11
Q 
False about Shigellosis
A)Potent and infective
B)Initial dysentery but not mild self-limited diarrhea 
C)causes ulceration and haemorrhage
D)none of the above
A

B

both are caused

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12
Q

Shiga toxin inhibits __ synthesis leading to cell death

A

eukaryotic protein

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13
Q

T or F

Antidiarrheal medications are contraindicated because they can prolong symptoms and delay Shigella clearance

A

T

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14
Q

Which is false?

a. There is no vaccine for typhoidal cases of diarrhoea
b. Humans are the sole reservoir
c. both are false
d. both are true

A

A

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15
Q

In S.enterica infection, there is hyperplasia of Peyer’s patches. This may mimic __

A

appendicitis

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16
Q

small erythematous maculopapular lesions on chest and abdomen found in patients with S.enterica

A

Rose spots

17
Q

False about Yersinia
A.involves ileum, appendix, and right colon
B.can mimic acute appendicitis
C.symptoms:arthralgia and erythema nodosum
D.virulence enhanced by calcium

A

D

Iron dapat

18
Q

T or F

Salmonella enteritidis causes typhoid

A

F

19
Q

strain of E.coli which has heat-labile and heat-stable toxins

A

Enterotoxigenic

20
Q

Heat-stable toxin of ETEC binds to ___ to increase cGMP

A

guanylate cyclase

21
Q 
Which has this virulence: attaching/effacing mechanism --> microvilli
A. ETEC
B. EPEC
C. EIEC
D. all of the above
A

B

22
Q 
Cows are natural reservoir for
A. EIEC
B. EPEC
C. ETEC
D. EHEC
A

D

23
Q

Official name of EHEC

A

E. coli O157:H7

24
Q 
Type of E.coli with Shiga-like toxin
A. EHEC
B. EIEC
C. ETEC
D. all of the above
A

A

25
Q 
Similar to Shigella biologically, no toxins in virulence
A. EHEC
B. EIEC
C. EAEC
D. all of the above
A

B

26
Q 
Which has dispersin?
A. EHEC
B. EIEC
C. EAEC
D. all of the above
A

C

27
Q

What does dispersin do?

A

neutralizes negative surface chargeof LPS

28
Q

Toxins –> ribosylation of ___ –>disruption of the epithelial cytoskeleton, tight junction barrier loss, cytokine release, and apoptosis

This is the pathogenesis of C.difficile. Fill in the blanks

A

small GTPases(Rho)

29
Q

identify

Made up of anadherent layers of inflammatory cells and debris at sites of colonic mucosal injury

A

pseudomembranes

30
Q

In pseudomembranous colitis, there are distended crypts due to ___

A

mucopurulent exudate

31
Q

causative agent of Whipple disease

A

Tropheryma whippeli

32
Q

morphology of Tropheryma whippeli
A. Gram (+) actinomycete
B. Gram (-) actinomycete
C. acid fast actinomycete

A

A

33
Q

post-morten exam manic of Whipple disease

A

presence of foamy macrophages and many argyrophilic rods in lymph nodes

34
Q 
false about Tropheryma whippeli
A.Periodic Acid-Schiff (PAS)-positive
B.acid fast positive
C.Gram positive
D. none of the above
A

B

35
Q 
Areas of bacteria-laden macrophages accumulation include all except: 
A.Mesenteric lymph vessels
B.Synovial membranes of affected joints
C.Cardiac valves
D.Brain
A

A

nodes, not vessels

PH 122 (17 decks)

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