muscle system Flashcards
function of muscle
- contract transiently and move the skeleton or fluids
- maintain a state of tone for support
two types of muscle
striated and smooth
striated muscle
striations running across the fibre, due to the arrangement of fibres and the contractile proteins contained
where is striated muscle found
skeleton ( support and movement) and cardiac muscle (rhythmic contraction)
smooth muscle
no clear structure - plain
where is smooth muscle found
around hollow organs
connective tissue sheet
external to epimysium and holds muscles together and separates them into functional groups - muscular fascia
layers of connective tissue coverings
epimysium, perimysium, endomysium
epimysium (outer layer)
surrounds a whole muscle
perimysium (middle layer)
denser ct surrounding a group of muscle fibres, allowing transmission of tension
endomysium (inner layer)
loose CT with reticular fibres (network of nerves and blood vessels)
muscle fibres
elongated multinucleate cell, contain a large number of rod-like myofibrils
myofibrils
organised protein components, composed of bundles of myofilaments
types of muscle fibres
type I, IIa, IIb
type I
long distance, slow twitch, more resistant to fatigue
type 2A
middle distance, fast twitch oxidative
type 2B
sprints, fast twitch glycolytic
sarcomeres
highly ordered repeating units of myofilaments
T tubule
wrap around the myofibril underneath the membrane, release ions to SR (sarcoplasmic reticulum)
Sacroplasmic reticulum
channel along the full length of the fibril filled with calcium, signals contraction initiation of the sarcomere
contractile proteins (2 types)
thick and thin filament
thick filament
bundle of myosin molecules, ATPase activity
thin filament
two strands of f-actin with spaced Ca++ regulatory proteins: troponin and tropomyosin
cross-bridge cycling
interaction of thick and thin filaments which creates contraction, iniated by the release of Ca++ ions
sliding filament theory
- during contraction the I-band (thin) is reduced but the A-band doesn’t,
- associated with the two filaments sliding past each other
neuromuscular junction
motor end plate activates the muscle fibre by releasing a neurotransmitter - acetylcholine
function of nmj
synaptic vessels, contains neurotransmitter- acetylcholine
excitation- contraction coupling
Ca++ entry allows the actin to alter the position of troponin which enables an attachment to myosin heads