Multiple Sclerosis

Question 1

N. MS is……….diseases Affect CNS…….matter (focal areas of………) and It can be relapsing or progressive course

Answer 1

Autoimmune, white, demyelination,

Question 2

N. MS is more in ……around age……?

Answer 2

Caucasian/ Northern European females, age 20-30 but it can be at any age.

Question 3

N. MS symptoms get worse with………?

Answer 3

High temperature

Question 4

N. What are the main S&S of MS?

Answer 4

Fatigue, weakness, numbness, tightness, blurred & double vision, bladder and bowel dysfunction, gait pb,

Question 5

N. What’s the MS effect on pregnancy?

Answer 5

The disease will be triggered by pregnancy especially 2-3 months following birth but there are fewer attacks during pregnancy and uncomplicated MS doesn’t affect the outcome of the pregnancy

Question 6

N. In diagnosis of MS: The best initial and best of all is……..of the brain &…… ( 95% sensitive in symptomatic ptn)
- The CSF test is done only if the MRI is non confirmatory ( if the ……..is higher than……mg/dl ) then this is against the diagnosis of MS, ⬆️…….index is found in ……-…… % of ptn with MS

Answer 6

MRI, spine, protein, 100, IgG, 70-90

Question 7

N. all disease modifying therapies are RELATIVELY contraindicated during pregnancy, …………and………. should be stopped in pregnancy

Answer 7

Interferon, glatiramer

Question 8

N. Name the drug that is used to help with walking speed in ptn with MS?

Answer 8

Dalfampridine

Question 9

N. What arethe main treatment options for MS?

Answer 9

3-5 days of IV corticosteroids for acute attack followed by oral medications tapered over a weeks, b-interferon, Glatiramer acetate, plasmapheresis ( in case ptn is unresponsive to steroids)

Question 10

N. What’s the drug given to help with spasticity in ptn with MS?

Answer 10

Baclofen , and for nocturnal spasticity give Tizanidine and diazepam

Question 11

N. 3. For ptn with MS who is complaining of bladder hyperactivity you can help by giving……..
While for urinary retention give…….

Answer 11

Oxybutynin , bethanecol

Question 12

N. Drugs to help with fatigue in MS are ……… & ……..

While in eractile dysfunction……..

Answer 12

Amantadine, fluoxetine , sildenafil acetate

Question 13

N. What’s the most common site that goes under demyelination in MS?

Answer 13

Periventricular white matter

Question 14

N. In MS exacerbation of symptoms occurs with hot temperature is called ……..phenomenon

Answer 14

Uhthoff phenomenon

Question 15

N. What’s lehermitte’s sign?

Answer 15

An electric like shock pain when ptn with MS flex his/her neck

Question 16

N. What’s the most common early presentation of MS?

Answer 16

Unilateral optic neuritis or retrobulbar neuritis

Question 17

N. The presence of…… …….. in the CSF in early cases indicate poor prognosis and it indicates synthesis of IgG

Answer 17

Multiple Oligoclonal bands