msk1 Flashcards
3rd pharyngeal pouch
inferir parathyroids
thymus
immune defiency associwthe w infectioun following live vaccines
deficiences of T cell mediated immunity
Graft vs host disease organs
liver , skin , GI tract
gvhd
graft T cell sensitizioatn against host MHC antigens
Lambert eaton myasthenic syndrome most often involves the
legs
neuropsych disturbances in which muscle disroder
fibromyaliga
soft tissue tendrenss in
fibromyalgia
NOT POLYMYALGIA rheuamtica
fat cell in a fibrous capsule
lipomas
clonal proliferation of benign melanocytes
congenital melanocytic nevi
failure of involution of mammary ridge
accessory nipple
hyperpigmentation, raised; epidermal thickening
hypergranulosis seen in
lichen planus
thickening of spinosum
acanthosis
thickening of stratum spinosum and stratum corneum produce what type of plaques
raised scaly plaques
deep brachial artery
radial nerve (foreram extensors)
medain nerve damage affects what artery
brachial artery
pain popping on external rotation mcmurray test
medial meniscal tear
excessive medail space widening of tibia; given a valgus force
MCL
excessive prodcution of mineralized bone
osteosarc`oma
frontal bossing seen in
achrondoplasia
and
rickets
however ricktes have decreased muscle tone causing lateral femoral and tibial bowing (genu varum)
foreign body causes what type of inlammation
granulomatous inflammation
triad of fibrous dysplasia (multiple osteolytic appearing lesions of hip and pelvis), endocrine abnormalities, and irregular cafe au lait spots suggests diagnosis of
McCune Albright syndrome
mccune albright syndrome: mutation causing
constitutive activatio nof G protein/Camp/adneylase cyclase causing gain of fucntion: Gs activity in mealoncytes : causing Cafe au lait macules (large, unilateral irregular border
endocrine abnormalities in mccune albright
precocious puberty, thyrotoxics, acromegaly
cafe au lait macules are what shaped
smaller, bilateral and smooth border
definition of heteroplasmy
different mitochondrial genomes within a single cell
what type of cells are langerhans cells
dendritic cells
derived from myeloid line
color of cavernous hemangiomas
soft blue
in contrast to bony enlargmeent in OA, involved joints in RA have
active synovitis, w warmth and spongy swelling
sitting up from supine position involes what muscles
external abdominal obliques, rectus abdominis, hip flexors (psoas)
rectus femoris, sartorius, tensor fascial lata, flex as well
fever, pruiritic skin rash, arthalgia 7-14 days after exposure to antigen
serum sickness
fibrinoid necoriss with neturophil infiltration
serum sickness (type III HSR - immune complex deposiotn)
acute serum sickness is what type of hsr
type 3
drug induced hyperesntiivity
type 3
charactersitic finding of type 3 hypersenstiviey seru m sickness
Low serum C3 and C4 levels
college quarterback: blow to arm whe ntackled mid throw
blow when externally rotated, abducted
anterior dislocation of humerus
flatting deltoid, protrusion of prominence
disseminated herpes simplex infection seen in
immunocompromised patietns
erythema multiforme is what type of process
cell mediated, Cd8+ lymphocytes
superior displacement of medial fragment of clavicle
SCM
inferior displacment of lateral fragment of clavicle
weight of arm and pec major
how do glucocorticoids cause osteoporsisi
decrease GI absorption of calcium, inhibit collagen syntehsis b y osteoblstst decrease gnrh (leading to hypogoandsim< and increase urinary calcium loss
GH deficeincy affects which bones
long and flat bones
unlike just long bones in achrondoplasia which also has midface hypoplsaia, macrocepahly
exaggerated INHIBITION of chrondocyte proliferation
FGFR3
which melanoma is associated with multinucleated giant melanocytes
lentigo maligna melanoma
mutation in gene responsible for myelin syntehssi in child
charco marie tooth disease
follwoing drug hypersentivity;
urticaria: raised erytehmatous plaques wheals caused by ig3 mediated degrnaulation of mast cells
urticaria
edema of superficial dermis
urticaria
abnormal narrowing of spinal canal occuring most commonly in lumbar region
spinal stenosis
neurogenic claudication
spinal stenosis
extension of lumbar spine (standing walking uprigh narrows spinal canla worsens symptoms
spinal stenossi
walking uphill/leaning on stroller / shopping cart: lumbar flexion reliees pain
spinal stenosis
spinal stenosi causes narorwing of spinal canal due to intervertebral disc herniation, ligamentum flavum _____
ligamentum flavum hypertrophy,
and osteophyte formation affecting facet joints
latissimus dorsi innervated by
thoracodorsal nerve
primary function: extension adduction medial rotation of humerus
poor melanin formation in melaoncytes
albinism
melanosome aggregates within cytoplasm of melanocytes
cafe au lait spots
LEMS vs MG
hyporeflexia, areflexia, autonomic symptoms (dry mouth, imptoence),
LEMS
rotates the scapula upward
serratus anterior
ige mediated degranulation vs ige independent mast cell activation
independent: following meds, including opioids, radiocontrast agents, antiboitics (vancomycin)
ige mediated: environmental exposures suchas foods or vespid stings
serum sickness is 7-14 days after
ige medaited/independnt 1 hour after
overuse injury of secondary ossficiation center of tibial tubercle
osgood schlatter disase
common cause of knee pain in young adolescent athletes
osgood schlatter causes insertion of what on to what
patella on to tibial tuberosity.
repertive quad contraction: OSgood schallter
chronic avusion: causes proximal patellar tendon to separte
separation of medial and lateral condyles of tibia
anterior intercondylar area
carpal tunnel defined by carpal bones on dorsal surface and ___ on volar surface
transverse carpal ligament
carpel tunnel contains
tendons of Flexor digitorum profundus + superficialis
flexor pollicis longus
piriformis passes through
greater sciatic foramen
sciatic nerve cross below pirfiromis muscle
piriforms does what
external hip rotation
muscle injury or hypertrophy can compress sciatic nerve: sciatica: piriformis syndorme
sciatica: pain tingling numbness in buttocks along nervedistirubtion
passes through lesser sciatic foramen and inserts on greater trochanter of femur
obturator internus
evert foot
superifical peroneal nerve
dorsiflexion of foot
toe extension
deep peroneal nerve
loss of dorsal foot sensation
injury to commmon peroneal nerve
loss of sensation at medial aspect of leg
saphenous nerve
actin contain fibroblasts
myofibroblasts
increased MMP and actin contain fibroblasts related to
contracture
inadequte vascularizaiton during healing
ulceration
wound dehiscne
rupturuing of preivous closed wound
insufficent granulatio and scar tissue
strong Th1 mediated response
Il2, ifn gamma, il 12
seen in tuberculoid m. leprae
symptoms: small number of hypopigmented well damracted skin palques; decreased sensation
more disseminated veriso of m. lepare is what repsosne
th2: il4, il5, il10; leprotamous leprosy
pt’s with strong cd4 th1 immune repsone will have indurated nodule in lepromin skin test
tuberculoid leprsoy
leprotamous leprsy tests negative to
lepromins kin test due to weak th1 mediatec cell immune repsone
medial band like calcifciations
monckeberg medial calcific scelrosis
multinucleated cells w intranuclear inclusiosn
vzv
eosinophilic cytoplasmic inclusions
molluscum bodies
in churg struss mononeuritis multiplex is common
asysmettic multifocal neuropahty due to vasculitis affeting epinerual vessels
