MS Tumors

Question 1

Most common location of bone tumors whether primary or metastatics

Answer 1

metaphysis

Question 2

Lab test marker for lymphoma

Answer 2

lactate dehydrogenase

Question 3

Lab test for myeloma

Answer 3

urine protein electrophoresis

Question 4

Lab test marker for osteosarcoma

Answer 4

alkaline phosphatase

Question 5

Most common bone tumor usually at knee, proximal humerus. Causes mechanical problems/compression. Tender, palpable mass

Answer 5

osteochondroma

Question 6

When do osteochondromas usually stop growing?

Answer 6

at skeletal maturity

Question 7

Common primary bone tumor with cortical thickening in long bones and spine. Characteristic night pain that resolves w/NSAIDs

Answer 7

osteoid osteoma

Question 8

Primary bone tumor and generally larger than osteoid osteomas. Doesn’t respond to NSAIDs. Have lytic appearance on x-ray

Answer 8

osteoblastoma

Question 9

Cartilaginous metaplasia of synovial tissue. Multiple loose bodies. Joint swelling/pain, locking. Middle age (40-60)

Answer 9

synovial chondromatosis

Question 10

What is the treatment for synovial chonromatosis?

Answer 10

loose body removal + synovectomy

Question 11

Bone that forms outside the skeleton, especially around a joint, in response to trauma and/or surgery. Often seen in patients with head injury or spinal cord injury

Answer 11

heterotopic ossification

Question 12

Treatment for heterotopic ossification to prevent further ossification

Answer 12

bisphosphonates

Question 13

Ectopic bone in inflamed muscle after injury/contusion. Pain, swelling, mass, warmth, reduced motion

Answer 13

myositis ossificans

Question 14

What is the difference between myositis ossificans and heterotrophic ossification?

Answer 14

heterotrophic ossification occurs at the joint while myosistis ossicifans occurs in the muscle usually after trauma

Question 15

Fluid filled cyst in proximal femur and proximal humerus. Age 5-15, boys. Well-demarcated metaphyseal lesion with cortical thinning. Often asymptomatic.

Answer 15

unicameral bone cyst

Question 16

Complication of unicameral bone cyst

Answer 16

can destroy physis w/resultant shortening

Question 17

Most common treatment for unicameral bone cysts

Answer 17

Aspiration/injection at 2 month intervals

Question 18

Expansile, lytic lesion with associated soft tissue mass. Epiphyseal areas. Pain and pathologic fracture presentation. locally aggressive, occasionally metastasize to lungs

Answer 18

giant cell tumor

Question 19

Treatment of giant cell tumors

Answer 19

curettage with high speed burr

Question 20

Expansile, lytic lesion
w/ thin shell of reactive bone. Fine bony blood filled spaces with thin fibrous septae. usually in . distal femur and proximal tibiaMRI -> fluid-fluid levels

Answer 20

aneurysmal bone cyst

Question 21

Common in childhood. Eccentrically located in metaphysis of long bones. Cortex can be thinned and gently expanded. Rim of dense bone

Answer 21

fibrous cortical defect/non ossifying fibroma (FCD-NOF)

Question 22

Benign fibro-osseous process in one or multiple bones. Mild expansion of bone, thinning of cortex, endosteal scalloping and “ground glass”appearance on X-ray. Progressive deformity with large lesions

Answer 22

fibrous dysplasia

Question 23

Benign tumor of cartilage in diaphysis of long bone & hand. Can turn into chondrosarcomas

Answer 23

enchondroma

Question 24

Rare epiphyseal tumor seen in knee, shoulder and hip. X-ray and histology similar to giant cell tumor. Well-circumscribed lesion (stippled calcification) on x-ray

Answer 24

chondroblastoma

Question 25

Frequent incidental finding on MRI – vertebral body. Larger lesions can cause instability, pathologic Fx, radiculopathy

Answer 25

hemangioma

Question 26

Most common soft tissue tumor. Arise anywhere on body. Usually asymptomatic, size variable. Soft and freely mobile on PE

Answer 26

lipoma

Question 27

Most common solitary peripheral nerve neoplasm. Numbness and parasthesia symptoms

Answer 27

schwannoma

Question 28

Proliferation of synovium to nodular villous masses. Painful knee with bloody effusion.

Answer 28

pigmented villonodular synovitis

Question 29

most common site for skeletal metastases

Answer 29

spine

Question 30

Peak incidence, males in second decade of life and older patients w/Pagets. increased bone density
and destruction, poorly defined margins. Skip lesions present on MRI. High risk of metastases

Answer 30

osteosarcoma

Question 31

Lytic lesion with poor margins and stippled calcification. Usually 40 yrs of age or older. Not chemo or radio sensitive. Tx is surgical resection

Answer 31

chondrosarcomas

Question 32

Presentation includes elevated calcium, renal failure, anemia, bone lesions

Answer 32

multiple myeloma

Question 33

Most common cancers to have bone metatastes

Answer 33

breast and prostate

Question 34

Difference between breast cancer and prostate cancer metastases

Answer 34

breast is usally osteolytic whereas prostate is usually blastic