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GI Exam 1 > Motility Agents and Antiemetics > Flashcards

Motility Agents and Antiemetics Flashcards

1
Q

How do enterochromaffin cells respond to increased pressure?

A

By increasing serotonin release

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2
Q

What does released serotonin activate?

A

Sensory neurons leading to CNS and sensory leading to enteric nervous system

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3
Q

What are 5-HT3 receptors?

A

Serotonin receptors on the sensory neurons leading to the CNS

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4
Q

What are 5-HT4 receptors?

A

Serotonin receptors on the pre-synaptic receptors of sensory neurons going to ENS

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5
Q

What gives positive input to postganglionic PS neurons?

A

Motilin receptor
Ach
Serotonin 5-HT4 receptor

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6
Q

What gives negative input to postganglionic PS neurons?

A

DA2 dopamine receptor

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7
Q

What type of M3 receptors are there?

A

Agonists

Antagonists

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8
Q

What type of dopamine-2 receptors are there?

A

Antagonist

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9
Q

What type of motilin receptors are there?

A

Agonists

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10
Q

What act on M3 receptor agonist and antagonist respectively?

A

Agonist: bethanacol
Antagonists: anticholinergics

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11
Q

What acts on dopamine antagonist receptors?

A

Metoclopramide

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12
Q

What acts on motilin receptor agonists?

A

Macrolides (antibiotics)

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13
Q

What type of drug is bethanacol?

A

M3 agonist anticholinesterase (multiple side effects)

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14
Q

What is metoclopramide?

A

D-2 receptor antagonists

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15
Q

What is a potential side effect of metoclopramide?

A

Parkinsonism (Parkinson like properties)

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16
Q

Where are motilin receptors found?

A

Postganglionic PS neuron

Intestinal SM

17
Q

What do the higher centers for emesis respond to?

A

Smells

Stress/anticipation

18
Q

What do the vestibular centers for emesis respond to?

A

Motion sickness

Visual stimuli

19
Q

What are the vagal afferent stimuli for emesis?

A

Mechanoreceptors
5-HT
Chemoreceptors

20
Q

What does CTZ in emesis stand for?

A

Chemoreceptor trigger zone

21
Q

What are the vestibular receptors for emesis?

A

Histamine-1 receptors

Muscarinic-1 receptors

GI Exam 1 (25 decks)

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