Molecular pathology of newer anti-cancer agents Flashcards
Vinblastine is an a_________ agent
antimicrotubule
etoposide inhibits t_______ II
topoisomerase
ifosamide binds directly to ___ to inhibit DNA synthesis by cross linking
DNA
Is conventional chemotherapy selective for tumour cells?
N
What are symptoms of conventional chemotherapy?
Myelosuppression (reduced production of blood cells0, hair loss, diarrhoea
Conventional chemotherapy is good for…
fast dividing tumours (eg germ cell tumours of testis, acute leukaemias, lymphomas, embryonal paediatric tumours, choriocarcinoma
Targeted chemotherapy exploits some difference between cancer cells and _____ cells
normal
How can differences be found between cancer cells and normal cells?
Gene arrays (looking at activity of genes), proteomics, tissue microarrays
M_________ antibody can be used to block growth factor binding to the growth factor receptor
Monoclonal
Small molecular inhibitor of growth factor A receptor normally binds to the i____ of the receptor so no activation as this intracytoplasmic domain is blocked
inside
Cetuximab is a ______ ____ against epidermal growth factor receptor
monoclonal antibody
Epidermal growth factor receptor leads to transcriptional upregulation of…
proliferation, angiogenesis, cell motility and invasion
Herceptin (Her-2)
Monoclonal antibody against epidermal growth factor receptor 2
In breast cancer there is over expression of Her-2 so too much signalling for transcription upregulation leading to p____
proliferation
Programmed cell death protein 1 is an immune checkpoint and inhibits _-___ response
T-cell
