Module 8 - Cardiac Cycle Flashcards

1
Q

Functions of Cardiac Cycle

A
  • Transport O2 & nutrients to all cells of body
  • Transport CO2 & waste from cells
  • Regulate body temperature & pH
  • Transport & distribute hormones & other substances
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2
Q

Right Atrium & Ventricle Function

A
  • Pumps blood to lungs
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3
Q

Left Atrium & Ventricle Function

A
  • Pumps blood to entire body
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4
Q

Left Ventricle

A
  • Contracts more forcefully to propel blood through entre circulatory system
  • Thicker wall
  • Requires more muscle
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5
Q

Right Ventricle

A
  • Thinner walls
  • Only pumps blood to lungs
  • Less forceful contraction
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6
Q

Heart Valves Purpose

A
  • Ensure 1 way flow of blood through heart (atrium to ventricle)
  • Prevent blood from backing up (returning to atrium during ventricle contraction)
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7
Q

Right Atrioventricular (AV) Valve

A
  • Tricuspid valve
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8
Q

Left Atrioventricular (AV) Valve

A
  • Bicuspid valve
  • Mitral valve
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9
Q

Aorta Function

A
  • Distributes blood from ventricle throughout body
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10
Q

Pulmonary Artery Function

A
  • Transports blood from right ventricle to lungs
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11
Q

Pulmonary Vein Function

A
  • Delivers blood back to heart after passing through lungs
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12
Q

Inferior Vena Cava Function

A
  • Delivers blood to heart from torso & lower limbs
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13
Q

Superior Vena Cava Function

A
  • Delivers blood from head & upper limbs to heart
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14
Q

Bundle of His Function

A
  • conduct action potentials from AV node to base(apex) of heart
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15
Q

Contractile Cells of Heart Components

A
  • Same proteins as actin/myosin
  • Arranged in bundles of myofibrils surrounded by SR
  • One nucleus
  • Many mitochondria
  • Short, branched cells
  • Joined by intercalated discs
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16
Q

Intercalated Disc Components

A
  • Tight junctions, bind cells
  • Gap junctions, movement of ions & current
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17
Q

Gap Junction Function

A
  • Allow myocardial cells to conduct action potentials from cell to cell
  • Without nerves
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18
Q

Nodal Cells

A
  • Contract weakly
  • Few contractile elements (myofibrils)
  • Spontaneously generate action potentials without nervous input
  • Self-excitable
  • Generate & transmit impulses through heart
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19
Q

Self-Excitability Pathway

A
  • Impulses originate in SA node (sinoatrial node)
  • Atria
  • AV node
  • Bundle of his
  • Purkinje fibers
  • Ventricular node
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20
Q

Sinoatrial Node (SA node) Permeability

A
  • Greater Na+ & Ca+ permeability
  • K+ permeability decreases overtime
  • Na+ permeability slightly higher than other cells
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21
Q

Sinoatrial Node (SA node) Characteristics

A
  • Fastest self-excitability
  • Slowest conduction speed
  • Located in upper posterior wall of right atrium
  • First to spontaneously depolarize
  • No stable resting potential
  • Create pacemaker potential
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22
Q

Threshold of SA Node

A
  • -40mV
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23
Q

Resting Potential of SA Node

A
  • -60mV
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24
Q

Steps of SA Node Action Potential

A
  • Membrane depolarizes to threshold
  • Special Ca++ channels open
  • Ca++ flows into cell
  • Ca++ channels close at same time K+ channels open
  • K+ flows out to repolarize cell
  • Cell returns to resting potential
  • Pacemaker potential begins depolarizing cell
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25
Myocardial Steps of Action Potential
- Action potential from SA node spreads through atrial muscle via gap junctions - Causing atrial contraction - Action potential travels to ventricles through AV node - Action potential travels through each branch of bundle of his to apex - Propagates through purkinje fibers - Rapidly distributes to ventricular muscle causing contraction
26
Action Potential Conduction Throughout Heart
- Speeds up through atrial muscle to ensure simultaneous contraction - AV node slows, holds up action potential (ensure atria finishes contraction) - Fast through bundle of his
27
Electrocardiogram (ECG)
- Represents electrical activity in areas of heart
28
P Wave of ECG
- Depolarization of atrial muscle - Leading to contraction
29
QRS Complex of ECG
- Depolarization of ventricular muscles - Leading to contraction - Longest waveform
30
T Wave of ECG
- Repolarization of ventricular muscles
31
Systole Phase
- Period of time heart muscle is contracting
32
Diastole Phase
- Period of time heart muscles relax - Chamber fills with blood
33
Cardiac Cycle Characteristics
- Combines heart events - Pressure & volume changes - ECG & valvular activity - Pressure changes for blood flow - Pressure gradient from high to low
34
Atrial Systole Phase
- Depolarization of atria (P wave) - Atrial pressure > ventricular pressure - AV valve already open - Blood flows into ventricles continuously - Ventricular volume increases - 20-30% of blood filling (end diastolic volume) - Atria contraction
35
Isovolumetric Ventricular Contraction Phase
- Depolarization of ventricles (QRS complex) - Ventricles contract - Increase in ventricular pressure - Ventricular pressure > atrial pressure - AV valve closes - No volume changes - Aortic pressure > ventricular pressure (aortic valve closes)
36
Ventricular Systole Phase
- Repolarization of ventricles (T wave) - Ventricular pressure > aortic pressure - Aortic valve opens - Blood leaves ventricles and flows into aorta - Ejection of blood from heart - Ventricular volume decreases - Some blood returns (end systolic volume)
37
Isovolumetric Relaxation Phase
- Ventricles relax causing pressure drop - Ventricular pressure < aortic pressure - Aortic valve closes - Ventricular pressure > atrial pressure - AV valve remains closed - No change in volume
38
Late Ventricular Diastole Phase
- Ventricles continue relaxing - Ventricular pressure < atrial pressure - AV valve opens - Blood flows into ventricles from atria - 80% of ventricular filling - Volume increases - P wave begins
39
Order of ECG Events
- atrial systole - iosvolumetric ventricular contraction - ventricular systole - isovolumetric relaxation - late ventricular diastole
40
Ventricular Filling
- 70-80% of blood enters relaxed ventricles during late ventricular diastole - 20-30% of blood enters during atria systole
41
Ejection Period
- Ventricular pressure > aortic pressure - Ventricles empty blood into aorta
42
LUB 1st Sound
- AV valve closes - During isovolumic ventricular contraction
43
DUB 2nd Sound
- Aortic & pulmonary semilunar valve close - During isovolumic relaxation
44
Cardiac Output (CO)
- Amount of blood in each ventricle pumps per minute - L/min
45
Heart Rate (HR)
- Number of heart beats per minute
46
Stroke Volume (SV)
- Amount of blood pumped by each ventricle during 1 contraction - Amount of blood ejected - mL/beat
47
End Diastolic Volume (EDV)
- Amount of blood in ventricle at end of diastole - mL
48
End Systolic Volume (ESV)
- Amount of blood in ventricles at end of systole - mL
49
Cardiac Output Equation
CO = HR x SV
50
Stroke Volume Equation
SV = EDV - ESV
51
Resting Values
- HR 70bpm - SV 70mL/beat - CO 5L/min - EDV 120mL - ESV 50 mL
52
Increasing Cardiac Output
- Increasing SV - Increasing HR - Increasing SV & HR
53
Altering Stroke Volume (SV)
- Input from ANS - ESV - EDV & preload
54
EDV & Preload Alteration
- Load on heart prior to contraction - Blood in ventricle stretches heart muscles - More blood in ventricles = higher EDV - More Ca++ into cell - More blood ejected & more forceful contraction - Lower ESV & higher SV
55
ESV Alteration
- Constriction on veins via ANS - Increases venous return - Repeated contraction & relaxation (exercise) - Pumps blood back to heart - Increases EDV, SV & CO
56
ANS Controls
- HR - Force of contraction
57
PSNS Controls
- Mostly SA & AV nodes - Atrial & ventricular muscles to lesser extent - Decreases HR through SA & AV Node - Decrease force of contraction to lesser extent
58
SNS Controls
- SA & AV nodes - Strongest on ventricular muscle - Increase HR & force of contraction
59
PSNS Activation
- Always activated at rest - Vagus nerve transmits signals to heart (vagal tone) - Shifts off if HR > 100bpm
60
PSNS Ach Release
- Nerves to heart activate release of Ach onto SA & AV nodes - Ach causes K+ channels to open - K+ leave cell creating hyperpolarization - Pacemaker potential decreases - Membrane takes longer to meet threshold & HR slows
61
SNS Ne Release
- Nerves to heart activate release of norepinephrine onto SA & AV Nodes - Causing Na+ & Ca++ channels to open - More positive ions enter SA nodal cell - Rapid depolarization & increase in pacemaker potential - Membrane reaches threshold faster & HR increases
62
Frank Stirling Law
- Increase of EDV causes increase in SV (vice versa) - Increase of blood volume causing increased stretch of muscles increasing force to pump blood out