MODULE 6 UNIT 2: WHITE BLOOD CELL ANOMALIES Flashcards
Owing to the fact that white blood cells are a heterogenous population, anomalies of white blood cells can be classified according to the
type of cell, cell parts affected and function
A. NUCLEAR ABNORMALITIES
- Hyposegmentation
- Hypersegmentation
Barr body (Sex chromatin)
B. CYTOPLASMIC ABNORMALITIES
- Alder-Reilly Bodies
- Auer Rods
- Chediak-Higashi granules
- Dohle Bodies
- Toxic granules
- Toxic vacuoles
C. ABNORMALITIES OF CELLS EXHIBITING PHAGOCYTOSIS
- LE cell
- Tart Cell
D. FUNCTION ABNORMALITIES
- Job syndrome
- Lazy Leukocyte Syndrome
- Chronic granulomatous disease
- Leukocyte Adhesion Disorder- I (LAD-I)
E. ABNORMALITIES ASSOCIATED WITH LYMPHOCYTES
- Atypical lymphocytes
- Basket cell/ Smudge cell
- Hairy cell
- Sezary cell
F. ABNORMALITIES ASSOCIATED WITH PLASMA CELLS
- Flame Cell
- Russell Bodies
- Grape Cell/ Berry Cell/ Morula Cell/ Mott Cell
- Dutcher’s Bodies
G. MONOCYTE/ MACROPHAGE LYSOSOMAL STORAGE DISORDERS
Lipid Storage Diseases
Mucopolysaccharidosis
Lipid Storage Diseases
Gaucher Disease
NiemannPick Disease
Fabry Disease
Tay-Sachs disease
Sandhoff disease
Sea Blue Histiocytes
Mucopolysaccharidosis
MPS I- Severe
MPS I- Attenuated
MPS II
MPS III
MPS IV
benign anomaly of neutrophils
Hyposegmentation
nucleus fails to segment properly
Hyposegmentation
bilobed nuclei
Hyposegmentation
o Dumbbell-shaped
o Spectacle-shaped
o Peanut-shaped
Hyposegmentation
o “Pince-nez”
Hyposegmentation
abnormality in the maturation of the neutrophils (abnormality in DNA synthesis)
Hypersegmentation
6 or more lobed nucleus
Hypersegmentation
o seen in the nuclear material
Appendage
o represents the second X chromosome in females o may be seen in 2-3% of neutrophils in females
Appendage
o NOT FOUND IN NORMAL MALES
Barr body
o a small, well-defined, round projection of nuclear chromatin
Barr body
o connected to the nucleus of the neutrophil by a single, fine strand of chromatin
Barr body
large purple-black coarse cytoplasmic granules
Alder-Reilly Bodies
accumulations of degraded mucopolysaccharides
Alder-Reilly Bodies