MIDTERM RODAKS

Question 1

a tetramer composed of two pairs of unlike polypeptide chains

Answer 1

hemoglobin molecule

Question 2

heme group

Answer 2

protoporphyrin IX 1 Fe2+

Question 3

bound to each of the four polypeptide chains

Answer 3

heme group

Question 4

carries oxygen from the lungs to the tissues

Answer 4

Hemoglobin, contained in RBCs

Question 5

Oxygen binds to the

Answer 5

ferrous iron in heme

Question 6

Each hemoglobin tetramer can bind [?] oxygen molecules

Answer 6

four

Question 7

Six structural genes code for the

Answer 7

Six globin chains of hemoglobin

Question 8

genes are on chromosome 16

Answer 8

Alpha and zeta

Question 9

genes are on chromosome 11

Answer 9

Epsilon lambda delta beta

Question 10

There is one copy of which globin genes per chromosome, for a total of two genes per diploid cell

Answer 10

1 delta
1 beta

Question 11

There are two copies of which globin genes per chromosome, for a total of four genes per diploid cell

Answer 11

Alpha and lambda

Question 12

The three hemoglobins found in normal adults are

Answer 12

Hb A, Hb A2, and Hb F

Question 13

composed of two ab heterodimers, is the pre ominant hemoglobin of adults

Answer 13

Hb A (a2b2)

Question 14

is the predominant hemoglobin in the fetus and newborn

Answer 14

Hb F (a2g2)

Question 15

is present from birth through adulthood, but at low levels

Answer 15

Hb A2 (a2d2)

Question 16

describes which hemoglobins are produced by the erythroid precursor cells from the fetal period through birth to adulthood

Answer 16

Hemoglobin ontogeny

Question 17

Complex genetic mechanisms regulate the sequential expression
of the polypeptide chains in the

Answer 17

embryo, fetus, and adult

Question 18

Heme provides negative feedback regulation on

Answer 18

protoporphyrin and globin chain production

Question 19

owing to cooperativity among the hemoglobin subunits in binding and re easing oxygen

Answer 19

sigmoid

Question 20

facilitates the delivery of oxygen from hemoglobin to the tissues

Answer 20

2,3-BPG

Question 21

the influence of pH on the release of oxygen from hemoglobin

Answer 21

Bohr effect

Question 22

[?] diffuses into the [?] and combines with [?] to form [?]

Answer 22

carbon dioxide
RBCs
water
carbonic acid

Question 23

The carbonic acid is then converted to

Answer 23

bicarbonate and hydrogen ions

Question 24

Most of the carbon dioxide is carried by hemoglobin as

Answer 24

H+