Description of Red Blood Cell (RBC) Abnormalities and Commonly Associated Disease States Flashcards
Abnormal variation in RBC volume or diameter
Anisocytosis
Large RBC (.8 mm in diameter), MCV .100 fL
Macrocyte
Large oval RBC
Oval macrocyte
Small RBC (,6 mm in diameter), MCV ,80 fL
Microcyte
Abnormal variation in RBC shape
Poikilocytosis
Small, round, dense RBC with no central pallor
Spherocyte
Elliptical (cigar-shaped)
Elliptocyte
oval (egg-shaped), RBC
ovalocyte
RBC with slit-like area of central pallor
Stomatocyte
Thin, dense, elongated RBC pointed at each end; may be curved
Sickle cell
Hexagonal crystal of dense hemoglobin formed within the RBC membrane
Hb C crystal
Fingerlike or quartz-like crystal of dense hemoglobin protruding from the RBC membrane
Hb SC crystal
RBC with hemoglobin concentrated in the center and around the periphery
Target cell (codocyte)
Fragmented RBC due to rupture in the peripheral circulation
Schistocyte (schizocyte)
RBC fragment in shape of a helmet
(keratocyte)
RBC with membrane folded over
Folded cell
Small, dense RBC with few irregularly spaced projections of varying length
Acanthocyte (spur cell)
RBC with blunt or pointed, short projections that are usually evenly spaced over the surface of cell; present in all fields of blood film but in variable numbers per field
(echinocyte)
Burr cell
RBC with a single pointed extension resembling a teardrop or pear
Teardrop cell (dacryocyte)
Hemolytic anemia
Anisocytosis
Diffuse basophilia
Howell-Jolly body
Immune hemolytic anemia
Spherocyte
Microangiopathic hemolytic anemia
Schistocyte (schizocyte)
microspherocytes
Helmet cell (keratocyte)
Extensive burns
Spherocyte
Schistocyte (schizocyte)
microspherocytes
Helmet cell (keratocyte)
Macroangiopathic hemolytic anemia
traumatic cardiac hemolysis
Schistocyte (schizocyte)
Helmet cell (keratocyte)
Megaloblastic anemia
Anisocytosis
Macrocyte
Oval macrocyte
Teardrop cell (dacryocyte)
Basophilic stippling
Howell-Jolly body
Pappenheimer bodies
Cabot ring
Iron deficiency anemia
Anisocytosis
Microcyte
Elliptocyte, ovalocyte
Myelodysplastic syndrome
Macrocyte
Basophilic stippling
Howell-Jolly body
Pappenheimer bodies
Cabot ring
Primary myelofibrosis
Teardrop cell (dacryocyte)
Myelophthisic anemia
Teardrop cell (dacryocyte)
Elliptocyte, ovalocyte
Chronic liver disease
Macrocyte
liver disease, alcoholism
Stomatocyte
Liver disease only
Target cell (codocyte)
Severe liver disease (spur cell anemia)
Acanthocyte
Hyposplenism
Howell-Jolly body
Pappenheimer bodies*
Postsplenectomy
Howell-Jolly body
Pappenheimer bodies*
Bone marrow failure
Macrocyte
Reticulocytosis
Macrocyte
Anemia of chronic inflammation
Microcyte
Sideroblastic anemia
Microcyte
Pappenheimer bodies*
Severe anemia; certain shapes helpful diagnostically
Poikilocytosis
Sickle cell anemia
Sickle cell
Sickle cell–b-thalassemia
Sickle cell
Thalassemia
Microcyte
Target cell (codocyte)
Teardrop cell (dacryocyte)
Basophilic stippling
Howell-Jolly body
Pappenheimer bodies*
Thalassemia major
Elliptocyte, ovalocyte
Hb E disease
Microcyte
Hb C disease
Hb C crystal
Folded cell
Hb SC disease
Hb SC crystal
Folded cell
Hemoglobinopathies
Target cell (codocyte)
Basophilic stippling
Pappenheimer bodies**
Unstable hemoglobins
Heinz body
Hb H disease
Hb H
Hereditary
Spherocyte
Elliptocyte, ovalocyte
Stomatocyte
Rh deficiency syndrome
Stomatocyte
Artifact
Stomatocyte
Neuroacanthocytosis
Acanthocyte (spur cell)
abetalipoproteinemia
Acanthocyte (spur cell)
McLeod syndrome
Acanthocyte (spur cell)
Uremia
Burr cell (echinocyte)
Pyruvate kinase deficiency
Burr cell (echinocyte)
After treatment for iron, vitamin B12, or folate deficiency
Diffuse basophilia
Lead poisoning
Basophilic stippling
Glucose-6-phosphate dehydrogenase deficiency
Heinz body
Oxidant drugs/chemicals
Heinz body
Stain dark blue and are called siderotic granules when observed in Prussian blue stain
Pappenheimer bodies
†Cells with similar morphology that are unevenly distributed in a blood film (not present in all fields) are likely due to a drying artifact in blood film preparation; these artifacts are sometimes called crenated RBCs
Burr cell (echinocyte)
**new methylene blue
Supravital Stain
***Stain dark blue and are called siderotic granules when observed in Prussian blue stain.
Appearance in Supravital Stain: Dark blue granules and f ilaments in cytoplasm (seen in reticulocytes)
Diffuse basophilia
Appearance in Supravital Stain and Wright’s stain: Dark blue-purple, fine or coarse punctate granules distributed throughout cytoplasm
Basophilic stippling
Appearance in Supravital Stain and Wright’s stain: Dark blue-purple dense, round granule; usually one per cell; occasionally multiple
Howell-Jolly body
Appearance in Supravital Stain: Round, dark blue-purple granule attached to inner RBC membrane
Heinz body
Appearance in Supravital Stain: Irregular clusters of small, light to dark blue granules, often near periphery of cell
Pappenheimer bodies
Appearance in Supravital Stain: Rings or figure-eights
Cabot ring
Appearance in Supravital Stain: Fine, evenly dispersed, dark blue granules; imparts “golf ball” appearance to RBCs
Hb H
Appearance in Wright Stain: Bluish tinge throughout cytoplasm; also called polychromasia (seen in polychromatic erythrocytes)
Diffuse basophilia
Appearance in Wright Stain: Not visible
Heinz body
Hb H
Appearance in Wright Stain: Irregular clusters of small, light to dark blue granules, often near periphery of cell
Pappenheimer bodies
Appearance in Wright Stain: Blue rings or figure-eights
Cabot ring
Inclusion Composed of: RNA
Diffuse basophilia
Inclusion Composed of: Precipitated RNA
Basophilic stippling
Inclusion Composed of: DNA (nuclear fragment)
Howell-Jolly body
Inclusion Composed of: Denatured hemoglobin
Heinz body
Inclusion Composed of: Iron
Pappenheimer bodies
Inclusion Composed of: Remnant of mitotic spindle
Cabot ring
Inclusion Composed of: Precipitate of b-globin chains of hemoglobin
Hb H
thrombotic thrombocytopenic purpura
Schistocyte (schizocyte)
microspherocytes
Helmet cell (keratocyte)
‘hemolytic uremic syndrome
Schistocyte (schizocyte)
microspherocytes
Helmet cell (keratocyte)
disseminated intravascular coagulation
Schistocyte (schizocyte)
microspherocytes
Helmet cell (keratocyte)