Module 4 Flashcards
What percentage of women over the age of 50 and the US will experience at least one fragility fracture in their lifetime
Forty
Women age 50 and under and men age 70 and under consume how many milligrams of calcium per day
1000
Men age 71 or older and women age 51 or older should consume how many milligrams of calcium per day
1200
For everyone under the age of 50 how many International units of vitamin D are recommended A-day
400 to 800
For everyone over the age of 50 how many IU of vitamin D do they recommend per day
800 to 1000
True or false Vitamin D is necessary for the absorption of calcium
True
What are the most common calcium supplements used
Calcium carbonate and calcium citrate
What are the most common vitamin D supplements used
Vitamin D2 or ergocalciferol and vitamin D3 cholecalciferol
What is the number one cause of fragility fractures
Falls
The NOF States that the most effective fall Prevention exercise plan includes
Twice weekly exercise for at least 6 months with a minimum of 50 hours of exercise
Bone formation and bone resortion that should be happening simultaneously is called what?
Bone remodeling
The best marker for bone formation
N-terminal propeptide
10 year hip fracture probability of more than 3% or a 10 year osteoporosis related fracture probability greater than 20%
FRAX
What are the 2 types for drug therapy
Antiresorpative or bone forming medication
Name some of the antiresorpitive drugs
Bisphosponates, RANK inhibitor denosumab, estrogen or hormone replacement therapy, calcitonins, SERMS
Types of bone forming medications
Steroid therapy’s, analogies of parathyroid hormone or PTH, teriparatide, Forteo
These types of medicines work to slow down the process of bone resorption and by binding to the hydroxapatite surface of bone
Bisphosphonates
4 types of Bisphosphonates Medication
Fosamax(alendronate) Boniva(ibandronate)
Actonel(Risedronate)
Reclast(zoledronic acid)
32 amino acid polypeptide hormone that the human thyroid produces to regulate calcium and phosphate levels
Calcitonin
Name the 2 types of Calcitonin
Fortical
Miacalcin
SERM
Selective estrogen receptor modulators
SERM drug
Raloxifene
True or false the fda has approved estrogen and hormone replacement therapies as a way to prevent osteoporosis
True
This is a 84 amino acid polypeptide that is naturally produced by the parathyroid gland
Parathyroid hormone
This drug is created using the 1st 34 amino acid groups of the 84 amino acid chain of natural parathyroid hormones
Teriparatide
When RANK binds with RANKL what happens
Activates osteoclast activity Which responds with reabsorbing bone mass
RANK inhibitor
Denosumab (Prolia)
What is the most efficient dose of calcium Absorption supplements
500 to 600 mg
Osteoanabolic drug
Teriparatide
This is a severe side effect of bisphosphonate use
Osteonecrosis of the jaw
How do selective astrogen receptor modulators reduce the risk of breast cancer
They block the effect of estrogen on the breast tissues
Estrogen is approved by the fda for the treatment of osteoporosis in post menopausal women
False
Overall medication regimen compliance for osteoporosis medication is about what %
65%
