module 3- gluconeogenesis Flashcards
primary function of gluconeogenesis in animals
maintaining adequate glucose levels in the blood
primary function of gluconeogenesis in plants
use glucose to synthesize starch, cellulose & sucrose
where does gluconeogenesis occur?
liver (mostly) and kidney
gluconeogenesis pathway
pyruvate into glucose
3 precursors of gluconeogenesis
lactate, amino acids & glycerol
lactate is converted back to pyruvate by ( ) and enters gluconeogenesis pathway
lactate dehydrogenase
amino acids are metabolized into ( )
intermediates
glycerol is derived from ( ) and converted into ( )
triacylglycerols, DHAP
what enzymes drives pyruvate -> oxaloacetate
pyruvate carboxylase
T or F: acetyl CoA is an obligate allosteric activator
T
where does pyruvate -> oxaloacetate reaction begin?
mitochondria
what enzyme drives fructose 1,6-BP -> fructose 6-P?
fructose 1,6-bisphosphatase
how is fructose 1,6-bisphosphatase regulated?
allosterically
what enzyme drives fructose 6-P -> glucose 6-P?
phosphoglucose isomerase
inputs & outputs of gluconeogenesis
inputs- 2 pyruvate, 4 ATP, 2 GTP, 2 NADH, 2 H, 6 H2O
outputs- 1 glucose, 4 ADP, 2 GDP, 6Pi, 2 NAD
glucose & gluconeogenesis are ( ) regulated
reciprocally