module 3- gluconeogenesis Flashcards

1
Q

primary function of gluconeogenesis in animals

A

maintaining adequate glucose levels in the blood

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2
Q

primary function of gluconeogenesis in plants

A

use glucose to synthesize starch, cellulose & sucrose

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3
Q

where does gluconeogenesis occur?

A

liver (mostly) and kidney

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4
Q

gluconeogenesis pathway

A

pyruvate into glucose

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5
Q

3 precursors of gluconeogenesis

A

lactate, amino acids & glycerol

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6
Q

lactate is converted back to pyruvate by ( ) and enters gluconeogenesis pathway

A

lactate dehydrogenase

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7
Q

amino acids are metabolized into ( )

A

intermediates

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8
Q

glycerol is derived from ( ) and converted into ( )

A

triacylglycerols, DHAP

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9
Q

what enzymes drives pyruvate -> oxaloacetate

A

pyruvate carboxylase

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10
Q

T or F: acetyl CoA is an obligate allosteric activator

A

T

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11
Q

where does pyruvate -> oxaloacetate reaction begin?

A

mitochondria

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12
Q

what enzyme drives fructose 1,6-BP -> fructose 6-P?

A

fructose 1,6-bisphosphatase

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13
Q

how is fructose 1,6-bisphosphatase regulated?

A

allosterically

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14
Q

what enzyme drives fructose 6-P -> glucose 6-P?

A

phosphoglucose isomerase

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15
Q

inputs & outputs of gluconeogenesis

A

inputs- 2 pyruvate, 4 ATP, 2 GTP, 2 NADH, 2 H, 6 H2O

outputs- 1 glucose, 4 ADP, 2 GDP, 6Pi, 2 NAD

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16
Q

glucose & gluconeogenesis are ( ) regulated

A

reciprocally

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17
Q

what pathway is favoured when glucose is abundant?

A

glycolysis

18
Q

what pathway is favoured when glucose is scare?

A

gluconeogenesis

19
Q

what is the major regulatory reaction of gluconeogenesis & what enzyme?

A

fructose 6-P -> fructose 1,6-BP

enzyme: fructose 1,6 bisphosphatase

20
Q

what is the major regulatory reaction of glycolysis & what enzyme?

A

fructose 6-P -> fructose 1,6-BP

enzyme: PFK

21
Q

AMP (inhibits/activates) PFK & stimulates (glycolysis/gluconeogenesis) = fructose 1,6 BP is ( ) and gluconeogenesis is ( )

A

activates, glycolysis
inhibited, slowed

22
Q

citrate (activates/inhibits) PFK & stimulates (enzyme?) = activation of (gluconeogenesis/glycolysis)

A

inhibits, PFK, gluconeogenesis

23
Q

pyruvate & PEP interconversion are ( ) regulated

A

reciprocally

24
Q

increased ADP = ( ) conversion of pyruvate -> PEP = favours (glycolysis/gluconeogenesis) & (ADP/ATP) production

A

inhibits, glycolysis, ATP

25
Q

allosteric regulator effect is highly dependent on its ( )

A

concentration

26
Q

T or F: lactate produced by muscles is converted to glucose in the liver via the cori cycle

A

T

27
Q

fructose 2,6-BP (activates/inhibits ) PFK = (glycolysis/gluconeogenesis) activation = (inhibits/activates) fructose 1,6 BP = (activates/deactivates) gluconeogenesis

A

activates, glycolysis, inhibits, deactivates

28
Q

low glucagon = ( ) insulin = favours which pathway

A

increased, glycolysis

29
Q

what pathway is present during starvation

A

gluconeogenesis

30
Q

what pathway is present in the fed state

A

glycolysis

31
Q

insulin resistance

A

excess glucose levels

32
Q
A
33
Q

What is the terminal enzyme?

A

Glucose 6-P

34
Q

increased ATP = what pathway

increased AMP = what pathway

A

gluconeogenesis, glycolysis

35
Q

increased fructose 2,6 BP = what pathway

A

glycolysis

36
Q

increased citrate = what pathway

A

gluconeogenesis

37
Q

increased acetyl CoA = what pathway

A

gluconeogenesis

38
Q

increased insulin = what pathway

A

glycolysis

39
Q

increased glucagon = what pathway

A

gluconeogenesis

40
Q

Main 3 enzymes in gluconeogenesis

A

pyruvate decarboxylase, fructose 1,6-bisphosphatase, glucose 6-phosphatase