Module 02: Cells and Tissues Flashcards
These are delineated as the smallest denominator of biotic organisms.
Cells
What are the basic tenets or postulates of the modern cell theory by Matthias Schleiden and Theodor Schwann?
(1) All cells are generated from preexisting cells.
(2) All cells have comparable biomolecules and biochemical reactions.
(3) All cells are constituted of a genetic material that is conveyed from one to another.
This organelle is a thin selectively permeable barrier that surrounds the interior surface of the cell; thus, delimiting it from the external environment. It is comprised of water-soluble molecules, such extrinsic and intrinsic proteins, nucleic acids, and fatty-acid-based lipids (phospholipids and sterols).
Plasma membrane
This organelle is also known as the nonnuclear content of the protoplasm, is delineated as the semifluid substance of a cell that is external to the nuclear membrane and internal to the cellular membrane.
Cytoplasm
This organelle is a membrane-enclosed organelle enveloped by a double-membrane known as the nuclear envelope. Moreover, it enacts a salient role in controlling and regulating cellular mechanisms along with conveying genetic materials that contain hereditary information.
Nucleus
This is constituted and underlies the interstitial fluids, blood plasma, cerebrospinal fluid (CSF). Moreover, this denotes the fluid that envelopes the exterior surface of cells. Apart from that, the volume of this is determined by the balance between sodium intake and renal excretion of sodium.
Extracellular Fluid
This extracellular fluid is the fluid between your tissues.
Interstitial Fluid
This extracellular fluid is the fluid that runs in your brain and your spine which allows lubrication and nutrient transport.
Cerebrospinal Fluid
These pertain to the substances that aid in digestion (gastric fluids) or act as lubricants (saliva).
Cellular Secretions
This is explicated as the most abundant material, jellylike substance composed of proteins and polysaccharides. Moreover, it is also an intricate network composed of an array of multidomain macromolecules organized in a cell/tissue-specific manner.
Extracellular matrix
This constituent of the plasma membrane generates the fabric of the membrane (phospholipid + cholesterol).
Membrane Lipids
This constituent of the plasma membrane compels the membrane to communicate with its environment, responsible for specialized membrane function.
Membrane Proteins
This constituent of the plasma membrane underlines glycoproteins and glycolipids. Glycocalyx (carbohydrate rich area) provides identity molecules for specific biologicals markers.
Membrane Carbohydrates
This constituent of the plasma membrane prods neighboring cells to adhere and to communicate, inhibit or aid in allowing movement of molecules between cells.
Cell Junctions
This generates the fundamental structure of the membrane. It is constituted of the hydrophobic tails that impede water-solute substances from permeating by engendering a boundary.
Phospholipids
The integral intent of this is to deliberately stiffen the membrane and decrease its water solubility to resolutely backup its structure.
Cholesterol
This is delineated as the primary determinant of the role of the membrane. One of its integral roles is to act as receptors for signal molecules and joining cells to each other and to the extracellular matrix.
Proteins
These are explicated as short chains of linked monosaccharides and are employed as identity molecules that prod cells to recognize who is who. It is located on the exterior surface of the membrane and generate a coating known as the glycocalyx.
Carbohydrates
What are the integral roles of the plasma membrane?
(1) Physical Barrier
(2) Selective Permeability
(3) Communication
(4) Cell Recognition
In this integral role of the plasma membrane, a protein (left) that spans the membrane may provide a hydrophilic channel across the membrane that is selective for a particular solute.. Some transport proteins (right) hydrolyze ATP as an energy source to actively pump substances across the membrane.
Transport
In this integral role of the plasma membrane, a membrane protein exposed to the outside of the cell may have a binding site that fits the shape of a specific chemical messenger, such as a hormone. When bound, the chemical messenger may cause a change in shape in the protein that initiates a chain of chemical reactions in the cell.
Receptors for signal trasnduction
In this integral role of the plasma membrane, a membrane protein may be an enzyme with its active site exposed to substances in the adjacent solution. A team of several enzymes in a membrane may catalyze sequential steps of a metabolic pathway as indicated (left to right) here.
Glycoprotein
Enzymatic Activity
In this integral role of the plasma membrane, some glycoproteins (proteins bonded to short chains of sugars which help to make up the glycocalyx) serve as identification tags that are specifically recognized by other cells.
Cell-to-Cell Recognition
In this integral role of the plasma membrane, membrane proteins of adjacent cells may be hooked together in various kinds of intercellular junctions.
Some membrane proteins (cell adhesion molecules or CAMS) of this group provide temporary binding sites that guide cell migration and other cell-to-cell interactions.
Cell-to-cell joining
In this integral role of the plasma membrane, the elements of the cytoskeleton (cell’s internal framework) and the extracellular matrix (fibers and other substances outside the cell) may anchor to membrane proteins.
Moreover, this aids in maintaining cell shape, fixes the location of certain membrane proteins, and plays a role in cell movement.
Attachment of the Cytoskeleton and the Extracellular Matrix (ECM)
This is delineated as a cellular transport in which substances such as ions and molecules move down their respective concentration gradients. It means that the substance tends to move from an area of higher concentration to an area of lower concentration.
Passive Transport
This passive transport pertains to lipid-soluble molecules diffuse directly through the lipid bilayer (usually small nonpolar molecules that readily dissolve in lipids).
Simple Diffusion
This passive transports pertains to a conveyance either through a) binding to carrier proteins or 2) through water filled channel proteins.
Facilitated Diffusion
This passive transport is prodded through protein carriers that are specific for one chemical. Moreover, in this, binding of solute engenders transport protein to change shape.
Carrier-mediated facilitated diffusion
This passive transport transpires through a channel protein that are typically selected on basis of size and change.
Channel-mediated facilitated diffusion
This passive transport pertains to the diffusion of a solvent through a membrane or a channel protein (aquaporin).
Osmosis
This refers to the ability of a solution to change the shape of cells by altering the cells; internal water volume.
Tonicity
This form of tonicity pertains to the same concentrations of nonpenetrating solutes as those found in the cells. Moreover, in this, they retain shape and exhibit no net loss or gain of water
Isotonic
This form of tonicity pertains to higher concentration of nonpenetrating solutes than seen in the cell Moreover, they exhibit weight loss due to the deliberate loss of water and are prodded to either shrivel or crenate.
Hypertonic
This form of tonicity pertains to more dilute than cells. They are compelled to either plump or lyse.
Hypotonic
This form of transport entails transport proteins that combine specifically and reversibly with the transported substances. This has the intrinsic faculty to convey solutes uphill, against a concentration gradient using energy.
Active Transport
This is an active transport that has the integral capacity to transport substances against a concentration (or electrochemical) gradient.
OK+. In this, a pump protein moves substances across the plasma membrane. Moreover, this form of transport utilizes energy of ATP hydrolysis.
Primary Active Transport
This form of active transport is delineated as as cotransport (coupled transport) of two solutes across the membrane. In this, energy is supplied by the concentration gradient created by primary active transport. Moreover, symporters move the transported substances in the same direction; antiporters move transported substances in opposite directions across the membrane.
Secondary Active Transport
This is a vesicular transport wherein, a large external particle (proteins, bacteria, dead cell debris) is surrounded by a pseudopod (“false foot”) and becomes enclosed in a vesicle (phagosome). Moreover, this occurs primarily in phagocytes (some white blood cells and macrophages).
Phagocytosis
This vesicular transport transpires when a plasma membrane sinks beneath an external fluid droplet contains small solutes. In this, membrane edges fuse, forming a fluid-filled vesicle. Apart from that, it transpires in most cells and is important for taking in dissolved solutes by absorptive cells of the kidney and intestine.
Pinocytosis (fluid phase of endocytosis)
This vesicular transport pertains to external substance binding to membrane receptors.
Receptor-mediated endocytosis
This vesicular transport pertains to vesicles pinching off from organelles and travel to other organelles to deliver or convey their cargo.
Vesicular trafficking
This vesicular transport pertains to the secretion or ejection of a substance from a cell. The substance is enclosed in a membranous vesicle, which fuses with the plasma membrane and ruptures, releasing the substance to the exterior.
Exocytosis
This is also delineated as voltage or rather the electrical potential energy resulting from the separation of oppositely charged particles
Membrane Potential
The resting membrane potential is determined mainly by the concentration gradient of ____________, while __________ drive the extracellular concentration.
Potassium, Sodium (PISO)
These are explicated as cell surface proteins that mediate the interaction between cells, or between cells and the extracellular matrix (ECM).
PRIMARY ROLES
(1) Utilized as an anchor to other molecules in the extracellular space
(2) Arms migrating cells employed to haul themselves past one another
(3) Signals that stick out from the blood vessel lining that rally WBCs to a nearby infected or injured area
(4) Mechanical sensors that transmit information about changes in the ECM
Cell Adhesion Molecules (CAMS)
These are delineated as diverse group of integral proteins that serve as binding sites which enact integral roles chemical signaling and contact signaling.
Plasma Membrane Receptors
This transpires when cells aggregate or convene, touch and recognize one another. Moreover, this is salient in development and immunity.
Contact SIgnaling
This process transpires when a ligand (chemical messenger) binds a specific receptor and initiates a response.
Chemical Signaling
These are ions or neutral molecules that bond to a central metal atom or ion. Moreover, they have the intrinsic faculty to donate pair of electrons to the central metal atom or ion to form a coordination complex.
Ligands
This pertains to the signals from the nervous system.
Neurotransmitters
This pertains to the signals from the endocrine system.
Hormones
This pertains to the chemicals that act locally and are rapidly destroyed.
Paracrine
How does a chemical signaling transpire?
(1) Ligand is sent out and binds to a specific receptor
(2) The receptor’s structure changes and cell proteins are altered
(3) Cell response