Modue 11 - Synaptic Integration Flashcards
what does the decision to fire an action potential depend on
- net sign
- strength of input
- location of synaps
- firing frequency of presyn neuron
what is spatial summation
closer to axon hillock, the less attenuation
so the more influence they have
what is temporal summation
more APs in suffiecient time get compounded onto the previous AP, which can push it above threshold
how can temporal summation influenece CA2+ channels and therefore NT levels
if enough APs fired before Ca2+ in presynap neuron runs out, then it accumulates
more NT released
and NT also accumulates in synapse
is neuronal transmission AM or FM
FM (frequency modulation)
the bigger the stimulus the higher the frq of APs
what is FM code
both frq and pattern of APs
pattern can influence temporal summation of the APs
which refractory period determines rate of APs
relative refractory period
how long are the refractory periods typically
ARP = 1ms
RRP = 4ms
how many APs allowed in 1s
200 APs
how is reward pathway an example of FM temporal summation
at normal rate - tonic = constant dop release
good - phasic = faster firing so faster dop release
bad - pause in activity = less dop release
