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CVPR 330 Blood > Mix of Study Materials for Blood Test 2 > Flashcards

Mix of Study Materials for Blood Test 2 Flashcards

1
Q

What is the protein (glue) that vWF recognizes and begins connecting to each other?

A

GPIb - IX - V

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2
Q

During platelet aggregation what is released ?

A

Dense Bodies

Alpha Granules

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3
Q

During platelet aggregation Fibrinogen connects 2 platelets via what receptors?

A

GPIIb / IIIa

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4
Q

Liquid plasma treats factor deficiencies for which there is no specific concentrate, such as ?

A

XI & XII

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5
Q

Cryoprecipitate treats what ?

A

XIII deficiency
vWF disease
Hemophelia A

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6
Q

Immune serum globulins (Gammaglobulins) are generated from what ?

A

Platelet Poor Plasma

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7
Q

Whole blood centrifuged via 4 degees celcius produces what ?

A

Platelet Rich Plasma

Packed Red Cells

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8
Q

Platelet Rich Plasma centrifuged via 20 degrees celcius produces what ?

A

Platelet Poor Plasma

Platelets

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9
Q

Platelet Poor Plasma frozen down to -70 degrees celcius produces what ?

A

Factor VIII deficient plasma

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10
Q

Packed Red Cells Frozen down to -80 degrees celcius produces what ?

A

Frozen red cells

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11
Q

Packed Red Cells produces what ?

A

Leukocyte poor Red Cells

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12
Q

Platelet Poor Plasma frozen down to -20 degrees celcius provides what ?

A

Fresh Frozen Plasma with a therapeutic concentration of ATIII.
Can be stored up to 1 year at -18 degrees celcius

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13
Q

Platelet Poor Plasma frozen down to -70 degrees celcius and then THAWED out produces what ?

A

Cryoprecipitate

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14
Q

Systems in place to prevent inappropriate activation of TPA ?

A

Aplha 2 - Plasmin Inhibitor
Alpha 2 - Macroglobulin
C1 Inactivator

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15
Q

What is the role of Alpha 2 - Antiplasmin ?

A

Inactivates any plasmin outside of the clot.

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16
Q

Gray platelet syndrome

A

Platelets cannot adhere to the endothelium

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17
Q

Sequestration

A

1/3 of platelets are sequestered by the spleen

18
Q

How does Thromboxane A2 regulate ADP ?

A

Increases release of ADP synthesized by the platelet membrane.

19
Q

How does PGI2 regulate ADP ?

A

Decreases the release of ADP synthesized by the endothelial cells lining the blood vessel.

20
Q

Transitory Thrombocytosis ?

450k - 600k

A

Exercise and stress releases sequestered platelets by the lungs and the spleen.

21
Q

Reactive Thrombocytosis ?

600k - 800k

A

Caused by increase production in the bone marrow as a result of inflammatory diseases, ect.

22
Q

Primary Thrombocytosis ?

1million

A

Caused by myeloproliferative disorder of stems cells.

23
Q

Treatment for vWF disease?

A 
Desmopressin Acetate = releases stored vWF
Replacement Factor VIII
vWF Concentrates 
FFP 
Cryoprecipitate
24
Q

Coumadin works by?

A

Inhibits vitamin K dependent factors (II, VII, IX, X, protein C, and protein S). Effect seen 3 - 5 days.

25
Q

Name 2 Xa Inhibitors ?

A

XARELTO

ELIQUIS ( apixaban)

26
Q

Name 5 Direct thrombin Inhibitors ?

PLHAB

A
  1. ) Hirudin, R-hirudin
  2. ) Lepirudin
  3. ) Bivalirudin
  4. ) Argatroban (Acova)
  5. ) Pradaxa
27
Q

Anticoagulants for patients with HIT ?

  • delay surgery
  • use heparin with protamine reversal during surgery
A

Hirudin, Lepirudin, or Argatroban.

But the most common used is Bivalirudin.

28
Q

What else can we give to conteract heparin besides Protamine ?

A

Polybrene 1 u / mL

29
Q

How do you calculate INR ?

A

(Patients PT / Mean Normal Prothrombin Time ) ^ International sensitive Index 1.297

30
Q

What is a normal INR ?

A

0.8 - 1.3

31
Q

With what INR value can we expect clotting ?

A

< 0.5

32
Q

With what INR value can we expect bleeding ?

A

3.0 - 5.0

33
Q

What is the recommended therapeutic range for PE, DVT, Prophylaxis, & A-Fib ?

A

2.0 - 3.0

34
Q

What is the recommended therapeutic range for prosthetic heart valves and recurrent systemic embolism?

A

3.0 - 4.5

35
Q

Plavix bind to what receptor on the platelet ?

A

P2Y12

36
Q

Fibrinogen binds to what receptor on the platelet?

A

GPIIb / IIIa (Alpha 2BBIII)

37
Q

Collagen binds to what receptor on the platelet ?

A

GP1A / 2A (Aplha 2B1)

38
Q

vWF binds to what receptor on the platelet ?

A

GP1b - IX - V

39
Q

Hemophelia is carried by females but expressed by ?

A

Males

40
Q

Gangrene AKA ?

A

Hemophilus B Septicemia

41
Q

Hemorrhagic Purpura is due to what?

A

Miningococcal Septicimia

CVPR 330 Blood (25 decks)

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