Mix of Study Materials for Blood Test 2 Flashcards
What is the protein (glue) that vWF recognizes and begins connecting to each other?
GPIb - IX - V
During platelet aggregation what is released ?
Dense Bodies
Alpha Granules
During platelet aggregation Fibrinogen connects 2 platelets via what receptors?
GPIIb / IIIa
Liquid plasma treats factor deficiencies for which there is no specific concentrate, such as ?
XI & XII
Cryoprecipitate treats what ?
XIII deficiency
vWF disease
Hemophelia A
Immune serum globulins (Gammaglobulins) are generated from what ?
Platelet Poor Plasma
Whole blood centrifuged via 4 degees celcius produces what ?
Platelet Rich Plasma
Packed Red Cells
Platelet Rich Plasma centrifuged via 20 degrees celcius produces what ?
Platelet Poor Plasma
Platelets
Platelet Poor Plasma frozen down to -70 degrees celcius produces what ?
Factor VIII deficient plasma
Packed Red Cells Frozen down to -80 degrees celcius produces what ?
Frozen red cells
Packed Red Cells produces what ?
Leukocyte poor Red Cells
Platelet Poor Plasma frozen down to -20 degrees celcius provides what ?
Fresh Frozen Plasma with a therapeutic concentration of ATIII.
Can be stored up to 1 year at -18 degrees celcius
Platelet Poor Plasma frozen down to -70 degrees celcius and then THAWED out produces what ?
Cryoprecipitate
Systems in place to prevent inappropriate activation of TPA ?
Aplha 2 - Plasmin Inhibitor
Alpha 2 - Macroglobulin
C1 Inactivator
What is the role of Alpha 2 - Antiplasmin ?
Inactivates any plasmin outside of the clot.
Gray platelet syndrome
Platelets cannot adhere to the endothelium
Sequestration
1/3 of platelets are sequestered by the spleen
How does Thromboxane A2 regulate ADP ?
Increases release of ADP synthesized by the platelet membrane.
How does PGI2 regulate ADP ?
Decreases the release of ADP synthesized by the endothelial cells lining the blood vessel.
Transitory Thrombocytosis ?
450k - 600k
Exercise and stress releases sequestered platelets by the lungs and the spleen.
Reactive Thrombocytosis ?
600k - 800k
Caused by increase production in the bone marrow as a result of inflammatory diseases, ect.
Primary Thrombocytosis ?
1million
Caused by myeloproliferative disorder of stems cells.
Treatment for vWF disease?
Desmopressin Acetate = releases stored vWF Replacement Factor VIII vWF Concentrates FFP Cryoprecipitate
Coumadin works by?
Inhibits vitamin K dependent factors (II, VII, IX, X, protein C, and protein S). Effect seen 3 - 5 days.
Name 2 Xa Inhibitors ?
XARELTO
ELIQUIS ( apixaban)
Name 5 Direct thrombin Inhibitors ?
PLHAB
- ) Hirudin, R-hirudin
- ) Lepirudin
- ) Bivalirudin
- ) Argatroban (Acova)
- ) Pradaxa
Anticoagulants for patients with HIT ?
- delay surgery
- use heparin with protamine reversal during surgery
Hirudin, Lepirudin, or Argatroban.
But the most common used is Bivalirudin.
What else can we give to conteract heparin besides Protamine ?
Polybrene 1 u / mL
How do you calculate INR ?
(Patients PT / Mean Normal Prothrombin Time ) ^ International sensitive Index 1.297
What is a normal INR ?
0.8 - 1.3
With what INR value can we expect clotting ?
< 0.5
With what INR value can we expect bleeding ?
3.0 - 5.0
What is the recommended therapeutic range for PE, DVT, Prophylaxis, & A-Fib ?
2.0 - 3.0
What is the recommended therapeutic range for prosthetic heart valves and recurrent systemic embolism?
3.0 - 4.5
Plavix bind to what receptor on the platelet ?
P2Y12
Fibrinogen binds to what receptor on the platelet?
GPIIb / IIIa (Alpha 2BBIII)
Collagen binds to what receptor on the platelet ?
GP1A / 2A (Aplha 2B1)
vWF binds to what receptor on the platelet ?
GP1b - IX - V
Hemophelia is carried by females but expressed by ?
Males
Gangrene AKA ?
Hemophilus B Septicemia
Hemorrhagic Purpura is due to what?
Miningococcal Septicimia
