Component Therapy / Test 3/3 Flashcards
What is the concept of component administration ?
use particular component for specific need
What ate the advantages of specific component administration ?
conserve blood, facilitate optimum treatment
Blood can be separated into what other components?
Packed cells
Plasma
Platelets
Cryoprecipitate
WHOLE BLOOD
- Approximately 400-550 ml plus
- 63 ml of CPD (anticoagulant)
- Hematocrit (HCT) – 36-44%
WHOLE BLOOD is stored at 1-6 C.
What beomes non functional ?
What factors decrease during storage?
platelets/granulocytes
Factors V and VIII
What are 3 Indications for Whole Blood ?
- Oxygen-carrying capacity / blood volume expansion
- Stable coagulation factors.
- Actively bleeding with > 25% blood loss
What is the best solution of the storage of whole blood ?
CPDA – 35 day outdate
Dose and administration of whole blood (adult) & (Peds)?
1g/dL Hgb or 3% Hct increase (adults)
8mL/kg – 1g/dL Hgb increase (peds)
Whole blood must be Administered through a blood filter within ?
4 hrs
Hematocrit of the donor unit is ?
60%
Dose and administration of whole blood (neonates?
10 – 15 mL/kg will increase the hemoglobin by about 3 g/dL
RED BLOOD CELLS Prepared from whole blood: What is the Hct range for (AS red cells) ?
(Hct 50-65%)
RED BLOOD CELLS Prepared from whole blood: What is the Hct range for (CPDA-1) & (CPD) ?
(Hct 65-80%)
What is the residual plasma content in RBC units?
~20 – 120 mL
Why would you transfuse RBCs ??
Increase oxygen carrying capacity and red cell mass
General guidelines for RBC transfusion for patients that have a Hgb > 10g/ml ?
increased oxygen consumption, e.g. sepsis
Signs and symptoms supporting need for transfusion
of RBC ?
- Syncope
- Angina
- dyspnea
- Tachycardia
- Rapid fall in Hgb (active bleeding)
Medical condition influencing need for transfusion of RBCs ?
- CHF
- Coagulopathy,
- DIC
- Acquired or congenital anemias
You should NEVER hang RBCs with what other infusions ?
- D5W,
- LACTATED RINGERS OR
- MEDICATIONS
What other infusions CAN you hang RBCs with ?
- NS,
- albumin or
- plasmanate
In Order to transfuse RBCs ABO and Rh must be compatible, you should transfuse over a period of ?
4 hrs with a filter
Regular PRBCs contain how many WBC ?
1-3x 10^9 WBC/unit
Leukoreduced units must retain what percentage of RBCs after filtration?
85%
3 reasons of why we should use Leukoreduced PRBCs ?
- Prevent febrile nonhemolytic reactions
- Reduce HLA alloimmunization
- Prevent TA-CMV infection