Mitosis Flashcards

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1
Q

3 key stages of the cell cycle.

A

1.) Interphase
2.) Nuclear division (mitosis/ meiosis)
3.) Cytokinesis.

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2
Q

What is the longest part of the cell cycle?

A
  • Interphase.
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3
Q

What 3 main things happen in interphase?

A

1.) Organelles replicate (ie. mitochondria/ ribosomes.)
2.) Cell grows
3.) DNA replicates

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4
Q

What are the 3 different stages of interphase?

A

1.) G1
2.) S-phase
3.) G2

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5
Q

What happens in G1 stage of interphase?

A
  • Cell grows.
  • Organelles (ie. mitochondria/ ribosomes) replicate.
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6
Q

What happens in S-phase of interphase?

A
  • DNA replication.
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7
Q

What happens in G2 phase of interphase?

A
  • Cell grows.
  • Replicated DNA is checked for any potential mutations -if there are mutations - the cell will die at this stage.
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8
Q

What is cytokinesis?

A
  • Divison of the cytoplasm/ cell membrane to create the new cells.
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9
Q

Difference between cells produced by mitosis vs meiosis.

A
  • Mitosis: two genetically-identical diploid cells produced.
  • Meiosis: four genetically different haploid cells produced
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10
Q

Give 4 reasons why cells divide

A

1.) Increase cell number
2.) Replace cells and tissues
3.) Produce genetically- identical cells.
4.) Assexual reproduction/ cloning.

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11
Q

What is meant by term “diploid cell?”

A
  • Each cell has 2 copies of each chromosome.
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12
Q

Give an EXAMPLE of where mitosis is important.

A
  • Important in clonal expansion of B- cells.
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13
Q

What is mitosis?

A
  • Part of cell cycle in which eukaryotic cell divides to produce two daughter cells- each with identical copies of DNA produced by the parent cell during DNA replication.
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14
Q

True or False

In all multi-cellular organisms, all cells retain the ability to divide.

A
  • False.
  • Not all cells retain the ability to divide.
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15
Q

What are 4 key stages of mitosis?

A

Prophase
Metaphase
Anaphase
Telophase

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16
Q

What are the outlines of mitosis?

A
  • One round of division
  • Genetically-identical cells made
  • Diploid cells made
17
Q

What happens in prophase?

A
  • Chromosomes condense and become visible.
  • Centrioles move to opposite poles of the cell.
  • Nuclear envelope breaks down.
  • Chromosomes appear as two sister chromatids - joined at centromere.
18
Q

What are centrioles?

A
  • Centrioles are structures responsible for creating spinle fibres.
19
Q

What happens in metaphase?

A
  • The chromosomes line along the equator of the cell.
  • Spindle fibres attach to centromeres.
20
Q

What is the centromere?

A
  • Middle part of chromosome that holds together two sister chromatids.
21
Q

What happens in anaphase?

A
  • Centromere splits
  • Spindle fibres contract (separating sister chromatids), pulling/ moving sister chromatids to opposite ends/ poles of the cell.
  • This stage requires ATP
22
Q

What happens in telophase?

A
  • Chromosomes no longer visible (as they uncoil.)
  • Nuclear envelope reforms
  • Spindle fibres disintegrate.
  • Cytokinesis: cytoplasm/ cell membrane splits to create two new genetically- identical cells.
23
Q

How do you calculate mitotic index?

A
  • The number of cells in mitosis (in field of view)/ the total number of cells (in field of the view.)
24
Q

What type of process is mitosis?

A
  • A controlled process.
25
Q

What can uncontrolled cell divison lead to the formation of?

A
  • Uncontrolled cell division can lead to the formation of tumours/ cancers.
26
Q

What are many cancer treatments directed at?

A
  • Many cancer treatments directed at controlling the rate of cell division.