Miscarriage Flashcards

1
Q

Define miscarriage

A

Pregnancy loss before 28weeks GA, <1000g fetal weight

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2
Q

Recurrence rates for miscarriages up to 4th pregnancy x3

A

2nd- 25%
3rd- 30%
4th- 30 to 40%

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3
Q

Maternal risk factors of miscarriage x5

A

Previous miscarriage
Maternal systemic infections
Psychological stress
Advance maternal age
Trauma

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4
Q

Classification of miscarriage x6

A

Threatened
Inevitable
Incomplete
Complete
Missed
Septic

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5
Q

In which miscarriages is the cervix open x2

A

Incomplete
Inevitable

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6
Q

In which miscarriages is the cervix closed x3

A

Threatened
Complete
Missed

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7
Q

Threatened miscarriage increases risk of the following maternal outcomes x4

A

Placenta previa
Placenta abruption
Manual delivery of placenta
C-section

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8
Q

Threatened miscarriage increases risk of the following perinatal outcomes x5

A

FGR
LBW infant
Preterm birth
Fetal and neonatal death
Preterm rupture of membranes

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9
Q

Fetal risk factors of miscarriage

A

Chromosomal abnormalities

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10
Q

Medical management of inevitable miscarriage if there’s signs of infection x2

A

DCN 100mg Po bd x7 days
Metronidazole 800mg stat

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11
Q

Which gestational age is appropriate for mva

A

Less than 9 weeks

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12
Q

Management of missed miscarriage at <12wks GA

A

Misoprostol 800mcg PV / 600mcg SL
Repeated every 3 hrs

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13
Q

Management of missed miscarriage at 12-24wks GA

A

Misoprostol 400mcg PV every 6 hours

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14
Q

Management of missed miscarriage at 24-28wks GA

A

Misoprostol 200mcg PV every 4hrs

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15
Q

Iv Medical Management of septic miscarriage x3

A

Benzyl penicillin 2MU IV
Gentamycin 320mg IV OD
Metronidazole 500mg IV

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16
Q

Oral medical management of septic miscarriage x2

A

DCN 100mg bd
Metronidazole 400mg tds x7 days

17
Q

MOA of metronidazole x3

A

Protein synthesis inhibitor. It disrupts helical structure of DNA and causes strand breakage > cell death

18
Q

MOA of doxycycline

A

Binds to 30s ribosomes during protein synthesis which inhibits growth of bacteria