Misc - Beta lactam antibiotics

Question 1

Betalactamase inhibitors (3)

Answer 1

1. Clavulanic acid
2. Sulbactam
3. Tazobactam

Question 2

MOA beta-lactamase inhibitors

Answer 2

Competitive inhibitor of beta-lactamase, preventing beta-lactam antibiotic hydrolysis

Question 3

Examples of clavulanic acid used with other beta lactams

Answer 3

Clavamox - amoxacillin + potassium clavulanate

Timentin = ticarcillin + potassium clavulante

Question 4

What is the difference between Sulbactam and Clav. acid

Answer 4

You cant take Sulbactam orally

Question 5

T/F - beta-lactamase inhibitors also have antimicrobial functions

Answer 5

FALSE - they are only used to augment drug

Question 6

Two types of Carbapenems. Which has least adverse reactions

Answer 6

Imipenem

Meropenem (least adverse reactions)

Question 7

What is Imipenem given with and why

Answer 7

Given with Cilastin to reduce production of nephrotoxic metabolite

Question 8

Spectrum of Imipenem

Answer 8

Broadest - used for resistant infections

Gram neg aerobes and anerobes incl pseudomonas

Question 9

Are carbapenems bacteristatic or cidal?

Answer 9

Cidal

Question 10

T/F Imipenem has post-antibiotic effect

Answer 10

True

Question 11

Adverse effect imipenem

Answer 11

Seizures

Question 12

What is Tazobactam used with? To treat what?

Answer 12

Piperacillin, to treat resistant Pseudomonas

Question 13

What are monobactams used for?

Answer 13

Gram neg, including pseudomonas

Used in penicillin allergic patients! Low immunogenicity

Question 14

Which beta lactam is suitable for patients with penicillin allergies

Answer 14

Monobactams (Aztreonam)

Question 15

Whats an example of a Monobactam

Answer 15

Aztreonam