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Pharm II > Lincosamines > Flashcards

Lincosamines Flashcards

1
Q

Are lincosamides static or cidal

A

Static

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2
Q

MOA lincosamides

A

Bind reversibly to 50s subunit

Inhibit transloation of peptides

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3
Q

Which lincosamides is used to treat Toxoplasma gondii?

A

Clindamycin

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4
Q

Which lincosamide only treats gram + aerobes?

A

Lincomycin

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5
Q

Is lincomycin effective against mycoplasma?

A

Yes, and gram + aerobes

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6
Q

What can you give lincomycin with to treat gram + and - infections in pigs and poultry

A

Lincomycin + Spectinomycin

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7
Q

Are lincosamides effective against anerobic infection? Gram negative?

A

Yes - Clindamycin is effective against gram - and anerobic infections

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8
Q

You have a dog with a Bacterioides infection. Which lincosamide will be effective?

A

Clindamycin (effective against anerobic bacteria)

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9
Q

Which lincosamide has high oral absorption

A

Clindamycin

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10
Q

With which lincosamide does food impair absorption

A

Lincamycin

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11
Q

Can you give lincosamides parenteral route

A

Yes - rapid, complete absorption and safe for rodents, horses, rabbits

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12
Q

Are Lincosamides lipid soluble?

A

Yes, lipid soluble bases

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13
Q

Distribution licosamides

A

Wide - lipid soluble! High tissue distribution

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14
Q

You have a cat with a menigneal infection. Can you prescribe a lincosamide?

A

Yes - Clindamycin attains high concentration in brain

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15
Q

Which lincosamide has low metabolism

A

Lincomycin

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16
Q

Which lincosamide is oxidated in liver

A

Clindamycin

17
Q

T/F - Clindamycin has active metabolites

A

True

18
Q

Excretion lincosamides

A

Bile

Urine

19
Q

T/F - lincosamides can be given orally to rodents, horses, rabbits

A

NEVER!! Causes entercolitis

20
Q

What adverse effects can lincomycin cause in dairy cows

A

Enterocolitis

Ketosis

21
Q

Lincosamide adverse effects in dogs, cats, pigs

A

Dogs: loose stool
Cats: vomiting
Pigs: diarrhea, anal swelling

22
Q

Bacteria resistance lincosamides

A

Efflux mechanism

Ribosomal alteration

23
Q

Does cross-resistance exist with lincosamides

A

YES

24
Q

Efficacy predicator of lincosamides

A

Type II (time dependent)

Pharm II (16 decks)

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