Lincosamines Flashcards
Are lincosamides static or cidal
Static
MOA lincosamides
Bind reversibly to 50s subunit
Inhibit transloation of peptides
Which lincosamides is used to treat Toxoplasma gondii?
Clindamycin
Which lincosamide only treats gram + aerobes?
Lincomycin
Is lincomycin effective against mycoplasma?
Yes, and gram + aerobes
What can you give lincomycin with to treat gram + and - infections in pigs and poultry
Lincomycin + Spectinomycin
Are lincosamides effective against anerobic infection? Gram negative?
Yes - Clindamycin is effective against gram - and anerobic infections
You have a dog with a Bacterioides infection. Which lincosamide will be effective?
Clindamycin (effective against anerobic bacteria)
Which lincosamide has high oral absorption
Clindamycin
With which lincosamide does food impair absorption
Lincamycin
Can you give lincosamides parenteral route
Yes - rapid, complete absorption and safe for rodents, horses, rabbits
Are Lincosamides lipid soluble?
Yes, lipid soluble bases
Distribution licosamides
Wide - lipid soluble! High tissue distribution
You have a cat with a menigneal infection. Can you prescribe a lincosamide?
Yes - Clindamycin attains high concentration in brain
Which lincosamide has low metabolism
Lincomycin