Cardio Drug Interactions

Question 1

What two drugs cause AV block

Answer 1

Diltiazem (Class 4 antiarrhythmic)

+

Beta-Blockers (Class 2 antiarrythmic)

Question 2

Which drugs when used together potentiate negative inotropic effects

Answer 2

Quinidine (class-1a antiarrythmic)

+

Beta-blockers (class antiarrythmic)

Both decrease conductance

Question 3

Which two drugs competitively inhibit eachother

Answer 3

Digoxin

+

Quinidine (competitive inhibition)

Question 4

Which drug inhibits secretion of another causing toxicity

Answer 4

Diltiazem inhibits tubular secretion of Digoxin

Question 5

Quinidine can cause toxic levels of which drug? Why?

Answer 5

Quinidine can cause Digitalis toxicity

Deplaces it from tissues, increasing concentration 2x

Question 6

Diltiazem increases concentration of which drug? How?

Answer 6

Diltaizem increases concentration of Digoxin

Inhibits tubular secretion of Digoxin

Question 7

Amiodarone increased concentrations of which drugs (6)

Answer 7

1. Digoxin
2. Quinidine (1a)
3. Procainamide (1a)
4. Phenytoin (1b)
5. Warfarin
6. Diatizam (4)