MIDTERMS ANTIINFLAMATORY Flashcards
compound with pain blocking properties
analgesic
only salicylates recommended for children
Choline magnesium trisalicylate and aspirin
the most used analgesic/antipyretic drug for children.
Acetaminophen
popular antiinflammatory agents block the inflammatory response but
with antipyretic (fever-blocking) and analgesic (pain-blocking)
properties.
Salicylates
extracted from willow bark, poplar trees, and other plants by
ancient peoples to treat fever, pain, and what we now call inflammation
Salicylates
Salicylates inhibit the synthesis of _____
prostaglandin
a potent vasoconstrictor that
normally increases platelet aggregation
thromboxane A2
, a vasodilator that inhibits
platelet aggregation
prostacyclin
treatment of mild to moderate pain, fever,
including rheumatoid arthritis and
osteoarthritis
Salicylates
Pharmacokinetics: Salicylates
absorbed directly from the stomach within 5 to 30 minutes
can occur with high levels of aspirin; dizziness, ringing in the ears, difficulty hearing, nausea, vomiting, diarrhea, mental confusion, and
lassitude can occur
Salicylism
Treatment of mild to moderate pain, fever, inflammatory
conditions; reduction of risk of transient ischemic attack or stroke;
reduction of risk of myocardial infarction
Aspirin
Adverse Effects: Aspirin
Nausea, vomiting, heartburn, epigastric
discomfort, occult blood loss, dizziness, tinnitus, acidosis
provide strong
antiinflammatory and analgesic effects without the adverse effects associated
with the corticosteroids
Nonsteroidal antiinflammatory drugs
NSAIDs block two enzymes, known as
COX-1 and COX-2
COX-1 turns _____ into
prostaglandins as needed in a variety of tissues.
arachidonic acid
active at sites of
trauma or injury when more prostaglandins are needed,
COX-2
its effects increases pain/inflammation
vasodilates
blocks platelet clumping
COX 2
Relief of the signs and symptoms of rheumatoid arthritis
and osteoarthritis; relief of mild to moderate pain; treatment of primary
dysmenorrhea; fever reduction.
Ibuprofen
treat moderate to mild pain and fever and often is used in place of the NSAIDs or salicylates. It has been the
most frequently used drug for managing pain and fever in children
Acetaminophen
acts directly on the thermoregulatory cells in the hypothalamus to cause sweating and vasodilation; this in turn causes the
release of heat and lowers fever
Acetaminophen
