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PHARMACO > MIDTERM IMMUNE DILATORS > Flashcards

MIDTERM IMMUNE DILATORS Flashcards

1
Q

drug used to energize the immune system when it is
exhausted from fighting prolonged invasion

A

immune stimulant

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2
Q

drug used to block or suppress the actions of the T
cells and antibody production

A

immune suppressant

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3
Q

specific antibodies produced by a single clone of
B cells

A

monoclonal antibodies

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4
Q

use of bacteria to produce chemicals normally produced by human cells

A

recombinant DNA technology

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5
Q

substances naturally produced and released by human cells that have been invaded by viruses

A

Interferons

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6
Q

is produced by harvesting human leukocytes.

A

Interferon alfa-n3 (Alferon N)

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7
Q

produced from Chinese hamster
ovary cells

A

Interferon beta-1a (Avonex)

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8
Q

s produced by Escherichia
coli bacteria.

A

Interferon gamma-1b (Actimmune)

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9
Q

act to prevent virus particles from replicating inside cells.

They
also stimulate noninvaded cells to produce
antiviral proteins,

A

Interferons

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10
Q

Pharmacokinetics: interferons

A

absorbed after subcutaneous or
intramuscular injection.

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11
Q

Inhibits the growth of tumor cells and enhances the
immune response

A

: Interferon Alfa-2b

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12
Q

communicate between lymphocytes, which stimulate cellular immunity and inhibit tumor growth

A

Interleukins

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13
Q

inhibit tumor growth by increasing lymphocyte numbers and
their activity

A

Natural interleukin-2

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14
Q

Indications: Metastatic renal cell carcinoma in adults, treatment of
metastatic melanoma

A

Aldesleukin

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15
Q

used to reduce the incidence of infection in patients with bone marrow
suppression

A

colony-stimulating factors

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16
Q

Increases the production of neutrophils in the bone
marrow

A

Filgrastim

17
Q

are used in conjunction with
corticosteroids, which block the inflammatory reaction and decrease initial
damage to cells.

A

Immune Suppressants

18
Q

beneficial in cases of organ
transplantation and in the treatment of autoimmune diseases

A

Immune Suppressants

19
Q

block the release of various cytokines involved in
the inflammatory response and activation of lymphocytes

A

Immune Modulator

20
Q

inhibit the secretion of
proinflammatory cytokines

A

lenalidomide and thalidomide

21
Q

inhibits the release of lymphocytes from lymph nodes into the
peripheral blood so they cannot migrate to activate immune

A

Fingolimod

22
Q

the first oral agent for the treatment of relapsing
forms of multiple sclerosis.

A

Fingolimod

23
Q

used in treating multiple
myeloma and myelodysplastic syndromes.

A

Lenalidomide

24
Q

used for
treating multiple myeloma and erythema nodosum leprosum

A

Thalidomide

25
Q

Prophylaxis for organ rejection in kidney, liver, and heart
transplants

A

Cyclosporine

26
Q

The only available interleukin-1 receptor antagonist is

A

anakinra (Kineret)

27
Q

The recommended dosage of Anakinra:

A

is 100 mg/d by subcutaneous injection

28
Q

Anakinra is contraindicated with any known allergy to

A

E. coli–produced
products

29
Q

Anakinra should not be combined with ____because of the potential for
serious infections

A

abatacept

30
Q

first monoclonal antibody approved for use, is a Tcell–specific antibody that was available as an IV agent.

A

Muromonab-CD3

31
Q

an antibody specific for lymphocyte receptor sites.

A

Alemtuzumab

32
Q

s indicated for treatment of
relapsing forms of multiple sclerosis.

A

Daclizumab

33
Q

a specific interleukin-6
blocker and is used for cryopyrin-associated periodic syndromes and juvenile
arthritis.

A

Canakinumab

34
Q

an antibody to immunoglobulin E, an important factor in
allergic reactions.

A

Omalizumab

35
Q

s specific to the antigenic site on respiratory syncytial virus

A

Palivizumab

36
Q

s a specific inhibitor of B-lymphocyte stimulator, which
inhibits the survival of B lymphocytes

A

Belimumab

37
Q

s a human cytotoxic T-cell antigen-4–blocking antibody.

A

Ipilimumab

38
Q

an integrin blocker that inhibits the movement of T cells across the gastric mucosa

A

Vedolizumab

39
Q

Actions: Monoclonal antibody that binds to and inhibits vascular
endothelial growth factor leading to decreased angiogenesis and cell
proliferation.

A

Bevacizumab

PHARMACO (19 decks)

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