MIDTERM IMMUNE DILATORS Flashcards
drug used to energize the immune system when it is
exhausted from fighting prolonged invasion
immune stimulant
drug used to block or suppress the actions of the T
cells and antibody production
immune suppressant
specific antibodies produced by a single clone of
B cells
monoclonal antibodies
use of bacteria to produce chemicals normally produced by human cells
recombinant DNA technology
substances naturally produced and released by human cells that have been invaded by viruses
Interferons
is produced by harvesting human leukocytes.
Interferon alfa-n3 (Alferon N)
produced from Chinese hamster
ovary cells
Interferon beta-1a (Avonex)
s produced by Escherichia
coli bacteria.
Interferon gamma-1b (Actimmune)
act to prevent virus particles from replicating inside cells.
They
also stimulate noninvaded cells to produce
antiviral proteins,
Interferons
Pharmacokinetics: interferons
absorbed after subcutaneous or
intramuscular injection.
Inhibits the growth of tumor cells and enhances the
immune response
: Interferon Alfa-2b
communicate between lymphocytes, which stimulate cellular immunity and inhibit tumor growth
Interleukins
inhibit tumor growth by increasing lymphocyte numbers and
their activity
Natural interleukin-2
Indications: Metastatic renal cell carcinoma in adults, treatment of
metastatic melanoma
Aldesleukin
used to reduce the incidence of infection in patients with bone marrow
suppression
colony-stimulating factors
Increases the production of neutrophils in the bone
marrow
Filgrastim
are used in conjunction with
corticosteroids, which block the inflammatory reaction and decrease initial
damage to cells.
Immune Suppressants
beneficial in cases of organ
transplantation and in the treatment of autoimmune diseases
Immune Suppressants
block the release of various cytokines involved in
the inflammatory response and activation of lymphocytes
Immune Modulator
inhibit the secretion of
proinflammatory cytokines
lenalidomide and thalidomide
inhibits the release of lymphocytes from lymph nodes into the
peripheral blood so they cannot migrate to activate immune
Fingolimod
the first oral agent for the treatment of relapsing
forms of multiple sclerosis.
Fingolimod
used in treating multiple
myeloma and myelodysplastic syndromes.
Lenalidomide
used for
treating multiple myeloma and erythema nodosum leprosum
Thalidomide
Prophylaxis for organ rejection in kidney, liver, and heart
transplants
Cyclosporine
The only available interleukin-1 receptor antagonist is
anakinra (Kineret)
The recommended dosage of Anakinra:
is 100 mg/d by subcutaneous injection
Anakinra is contraindicated with any known allergy to
E. coli–produced
products
Anakinra should not be combined with ____because of the potential for
serious infections
abatacept
first monoclonal antibody approved for use, is a Tcell–specific antibody that was available as an IV agent.
Muromonab-CD3
an antibody specific for lymphocyte receptor sites.
Alemtuzumab
s indicated for treatment of
relapsing forms of multiple sclerosis.
Daclizumab
a specific interleukin-6
blocker and is used for cryopyrin-associated periodic syndromes and juvenile
arthritis.
Canakinumab
an antibody to immunoglobulin E, an important factor in
allergic reactions.
Omalizumab
s specific to the antigenic site on respiratory syncytial virus
Palivizumab
s a specific inhibitor of B-lymphocyte stimulator, which
inhibits the survival of B lymphocytes
Belimumab
s a human cytotoxic T-cell antigen-4–blocking antibody.
Ipilimumab
an integrin blocker that inhibits the movement of T cells across the gastric mucosa
Vedolizumab
Actions: Monoclonal antibody that binds to and inhibits vascular
endothelial growth factor leading to decreased angiogenesis and cell
proliferation.
Bevacizumab
