MIDTERM ANTIFUNGAL Flashcards
An infection caused
by a fungus is called a
mycosis
fungus has a cell membrane that contains
ergosterol
a fungus that is normally found on mucous membranes
Candida
Treatment for candidiasis meningitis,
Fluconazole
treatment for invasive aspergillosis
isavuconazonium
treatment for blastomycosis
ITRACONAZOLE
treatment for onchomycosis
terbinafine
work by inhibiting glucan synthesis. Glucan is an enzyme
that is present in the fungal cell wall but not in human cell walls.
echinocandins
treatemnt for candidemia infection of blood stream
Anidulafungin
treatment for esophageal candidiasis
Micafungin
antifungals that inhibit the synthesis of ergosterol
Posaconazole
voriconazole
isavuconazonium
inhibits cytochrome P-450 2D6 (CYP2D6)
enzyme system
a better choice for patients who need to take drugs metabolized by the cytochrome
Terbinafine
also available as a shampoo
Ketoconazole
been associated with severe liver toxicity and are
contraindicated with liver failure.
Terbinafine
and isavuconazonium
an herb frequently used to treat migraine headache and menstrual problems
ergot
Drugs in this
class include anidulafungin (Eraxis), caspofungin (Cancidas), and
micafungin (Mycamine)
Echinocandin Antifungals
l drugs work to alter the cell permeability of the fungus,
causing prevention of replication and fungal death
topical antifungal
These drugs are not absorbed systemically and do not undergo metabolism or excretion in the body.
topical antifungal drugs
work by inhibiting glucan synthesis
echinocandins
an enzyme that is present in the fungal cell wall but not in human cell walls.
Glucan
a very potent drug with many unpleasant adverse effects its use is reserved for progressive, potentially fatal infections
Amphotericin B
a less toxic drug that alters the cell membrane of susceptible fungi
Flucytosine
an older antifungal that acts in changing cell membrane permeability and causing cell death.
Griseofulvin
Patients who receive amphotericin B should not take other nephrotoxic drugs such as____ because of the increased risk of
severe renal toxicity
nephrotoxic antibiotics or antineoplastics, cyclosporine, or corticosteroids
in topical forms. Fungi that cause these
mycoses are called
dermatophytes
can cause intense, local burning and irritation and should be discontinued if
these conditions become severe.
Econazole
stains skin and clothing bright purple; in addition, it is very toxic when absorbed
Gentian violet
should not be
used for longer than 4 weeks due to the risk of adverse effects and possible
emergence of resistant strains o
Naftifine, oxiconazole, and sertaconazole
should not be used for
longer than 6 weeks due to the risk of adverse effects and possible emergence
of resistant strains of fungi
Sulconazole
must be applied with the supplied flow-through brush ANTIFUNGALapplicator
Efinaconazole
