MIDTERM 02 - Solid Dosage Forms Flashcards
Intimate mixtures of dry, finely divided drugs and/or chemicals used externally or internally
Powders
Mixtures that liquefy when in close and prolonged contact with one another
Eutectic mixtures
Done to obtain quantitative data on the size, distribution, and shapes of drug and other components to be used in pharmaceutical formulation
Particle size analysis
Particles are passed by mechanical shaking through a series of sieves (Method for particle size analysis)
Sieving
Is made of wire woven cloth from brass, bronze, or other suitable wire
Sieves
Particles are sized through a calibrated grid background or measuring device (Method for particle size analysis)
Microscopy
Measuring the settling velocity of particles (Stokes’ law) (Method for particle size analysis)
Sedimentation rate
Determined by the reduction in light reaching the sensor as it passes through a sensor (Method for particle size analysis)
Light energy diffraction/Light scattering
Pulsed layer is fired through an aerosolized particle spray and photographed in 3 dimensions (Method for particle size analysis)
Laser holography
Particle is driven by an airstream will hit a surface in its path; separated into various size ranges (Method for particle size analysis)
Cascade impaction
A mechanical process of reducing particle size of solids
Comminution
2 types of comminution of drugs (SL)
Small scale, Large scale
3 types of small-scale comminution of drugs (TLP)
Trituration, Levigation, Pulverization by intervention
Process of grinding a drug in a mortar and pestle to reduce its particle size (Types of small scale comminution)
Trituration
Has a non-porous, smooth surface and is used for suspensions and ointments (Types of mortar and pestle)
Glass
Used for crystalline solids (Types of mortar and pestle)
Wedgewood
Used for soft aggregates/crystalline (Types of mortar and pestle)
Porcelain
Not to be used in reactive substance (Types of mortar and pestle)
Metal
Process of separating fine particles from coarse by grinding in water (Types of small scale comminution)
Levigation
Process of reduction of particle size with the aid of a second agent that can be readily removed from the pulverized product (Types of small scale comminution)
Pulverization by intervention
Example of mill & pulverizer used for large scale comminution of drugs
FitzMill comminutor
5 ways of mixing/blending powders (TSGST)
Trituration, Spatulation, Geometric dilution, Sifting, Tumbling
Process of using a spatula on a sheet of paper/ointment tile (Ways of mixing/blending powders)
Spatulation
Used when a small amount of potent substance is mixed with a large amount of diluent (Ways of mixing/blending powders)
Geometric dilution