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PH 107 - Pharmaceutical Dosage Forms, Drug Delivery Systems, and Medical Devices (Lec.) > FINAL 01 - Liquid Dosage Forms > Flashcards

FINAL 01 - Liquid Dosage Forms Flashcards

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USMLE® Step 1 flashcards
1
Q

In physicochemical terms, __________ may be prepared from any combination of solid, liquid, or gas

A

Solutions

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2
Q

In pharmaceutical terms, these are liquid preparations which contains one or more substances dissolved in a suitable solvent or mixture of mutually miscible solvents

A

Solutions

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3
Q

Refers to the maximum concentration at which a solution can be formed with that agent/solute and that solvent

A

Solubility

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4
Q

Solubility is expressed as __________

A

g/mL

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5
Q

Most useful solvent next to water; forms a hydroalcoholic mixture with water (Solvents for liquid preparations)

A

Alcohol, USP

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6
Q

Contains not less than 99.5% ethyl alcohol by volume; used when an essentially water-free alcohol is desired (Solvents for liquid preparations)

A

Dehydrated alcohol, USP

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7
Q

A hydroalcoholic solvent in pharmaceutical processes and preparations; prepared by mixing equal volumes of alcohol, USP and purified water, USP (Solvents for liquid preparations)

A

Diluted alcohol, NF

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8
Q

Solvent used as a rubefacient, soothing rub, germicide, skin cleaner, and vehicle (Solvents for liquid preparations)

A

Rubbing alcohol

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9
Q

Is added to prevent accidental or abusive oral ingestion

A

Denatorium benzoate

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10
Q

Is a clear syrupy liquid with a sweet taste; used as a preservative, stabilizer and auxiliary solvent, and for internal preparations (Solvents for liquid preparations)

A

Glycerin, USP

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11
Q

Used as a rubefacient, soothing rub, vehicle, and preparing needles and syringes (Solvents for liquid preparations)

A

Isopropyl rubbing alcohol

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12
Q

Miscible with water and alcohol; a useful solvent used as a substitute for glycerin (Solvents for liquid preparations)

A

Propylene glycol, USP

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13
Q

Is obtained by distillation, ion exchange treatment, reverse osmosis, or other suitable process (Solvents for liquid preparations)

A

Purified water, USP

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14
Q

2 basic types of water preparation (WP)

A

Water for injection, Purified water

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15
Q

3 methods of preparation of pharmaceutical water (DRI)

A

Distillation, Reverse osmosis, Ion-exchange

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16
Q

Is nature’s water purification process; consists of the vaporization and condensation of water (Methods of preparation of pharmaceutical water)

A

Distillation

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17
Q

Uses a semi-permeable membrane to remove ions, molecules, and larger particles from drinking water (Methods of preparation of pharmaceutical water)

A

Reverse osmosis

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18
Q

Involves the passage of water through a column of cation and anion exchanges consisting of resins producing demineralized or deionized water (Methods of preparation of pharmaceutical water)

A

Ion-exchange

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19
Q

2 kinds of solutions (AN)

A

Aqueous, Non-aqueous

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20
Q

Water-based; uses water as main solvent (Kinds of solutions)

A

Aqueous solution

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21
Q

Does not use water but a different solvent (Kinds of solutions)

A

Non-aqueous solution

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22
Q

Uses alcohol as main solvent (Types of non-aqueous solution)

A

Hydroalcoholic

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23
Q

Uses oil as main solvent (Types of non-aqueous solution)

A

Oleaginous

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24
Q

Uses ether as main solvent (Types of non-aqueous solution)

A

Ethereal

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25
Q

Also known as “medicated waters”; a clear, saturated aqueous solution of volatile oils or other aromatic substances (Types of aqueous solutions)

A

Aromatic waters

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26
Q

2 methods of preparation for aromatic waters (DS)

A

Distillation/Cohobation method, Solution method

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27
Q

Method used for strong rose water (Methods of preparation for aromatic waters)

A

Distillation/Cohobation method

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28
Q

Includes direct solution method and alternate solution method with dispersing agent (Methods of preparation for aromatic waters)

A

Solution method

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29
Q

Are concentrated aqueous solutions of sugars or sugar substitute with or without flavoring agents and medicinal substances (Types of aqueous solutions)

A

Syrups

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30
Q

Masks salty taste of iodine, bromine, and chlorine (Examples of syrups)

A

Glycyrrhiza syrup

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31
Q

Masks the salty taste of saline medicaments (Examples of syrups)

A

Raspberry syrup

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32
Q

A syrup with 85% w/v; is a self-preserving solution with a specific gravity of 1.313 (Examples of syrups)

A

Simple syrup

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33
Q

The sugar most frequently employed in syrups

A

Sucrose

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34
Q

Is a syrup prepared by dissolving 85 g of sucrose in purified water to make 100 mL of syrup

A

Syrup, NF (Simple syrup)

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35
Q

Enhances the appeal of the syrup; correlates with the flavorant employed

A

Colorant

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36
Q

Is a rapid method; overheating may cause caramelization (Methods of syrup preparation)

A

Solution with aid of heat

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37
Q

Is a slower method; suited for components that are heat-labile (Methods of syrup preparation)

A

Solution by agitation w/o aid of heat

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38
Q

Uses percolator; an official method in USP for the preparation of syrup (Methods of syrup preparation)

A

Percolation

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39
Q

It increases the stability of syrups and minimizes microbial contamination (Methods of syrup preparation)

A

Reconstitution

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40
Q

Intended for body orifices as cleansing agents or antiseptics (Types of aqueous solutions)

A

Douches

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41
Q

Used to remove foreign particles and discharges from the eyes (Kinds of douches)

A

Eye douche

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42
Q

Used to prepare the interior of the throat for an operation and to cleanse it in suppurative conditions (Kinds of douches)

A

Pharyngeal douche

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43
Q

Used to cleanse nasal passage (Kinds of douches)

A

Nasal douche

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44
Q

Used for irrigative cleansing of the vagina for hygienic effects (Kinds of douches)

A

Vaginal/Urethral douche

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45
Q

Is the practice of washing or flushing the vagina with water or other fluids

A

Vaginal douching

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46
Q

A fluid injected into the lower bowel by way of the rectum; used to relieve constipation or for bowel cleansing (Types of aqueous solutions)

A

Enemas/Clyster

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47
Q

2 types of enemas (ER)

A

Evacuation, Retention

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48
Q

Rectal insertion employed to evacuate the bowel (Types of enemas)

A

Evacuation enema

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49
Q

Held in the rectum and sigmoid colon for a specific period of time so the colon can absorb most of the solution (Types of enemas)

A

Retention enema

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50
Q

3 kinds of retention enema (NMD)

A

Nutritive, Medicated, Diagnostic

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51
Q

A retention enema with local effects

A

Hydrocortisone

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52
Q

A retention enema with systemic effects

A

Aminophylline

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53
Q

Is a liquid which is held in the mouth passively or swilled around the mouth (Types of aqueous solutions)

A

Mouthwash/Mouth rinse/Oral rinse/Mouth bath

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54
Q

Used for temporary relief of pain, soreness, and irritation in the mouth (Types of dental solutions)

A

Benzocaine

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55
Q

Used in dentistry by sterilization of deep root canals (Types of dental solutions)

A

Camphorated parachlorophenol

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56
Q

Used as a chemo mechanical cleansing and deriding agent (Types of dental solutions)

A

Carbamide peroxide topical solution

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57
Q

Used as a freshening mouth cleanser; have benzyl alcohol as a local anesthetic (Types of dental solutions)

A

Cetylpyridinium chloride solution and lozenges

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58
Q

Solution applied to teeth to reveal remaining plaque; the tablet has the same effect but it is not swallowed (Types of dental solutions)

A

Erythrosine sodium topical solution and soluble tablets

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59
Q

Applied topically to dental cavities and dental protective (Types of dental solutions)

A

Eugenol

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60
Q

Used as a topical dental anesthetic (Types of dental solutions)

A

Lidocaine oral spray

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61
Q

Used for oral fungal infections by retaining in the mouth as long as possible before swallowing (Types of dental solutions)

A

Nystatin oral suspension

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62
Q

Are electrolytes in a carboxymethylcellulose base used for relief of dry mouth and throat in xerostomia (Types of dental solutions)

A

Saliva substitutes

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63
Q

Used for the treatment of nasopharyngeal conditions by forcing air from the lungs through a gargle that is held in the throat and subsequently expectorated (Types of aqueous solutions)

A

Gargle

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64
Q

Are expressed juices prepared from fresh ripe fruits, used in syrups which are employed as vehicles (Types of aqueous solutions)

A

Juices

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65
Q

Juices expressed from fresh plants and evaporated were formerly known as __________

A

Inspissated juices

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66
Q

Are pharmaceutical products that are used inside, outside, or around the ears to exert therapeutic effect (Types of aqueous solutions)

A

Otic/Aural preparation

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67
Q

Is a condition whereby water has become trapped between the cerumen impaction and the tympanic membrane

A

Swimmer’s ear

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68
Q

Are liquid, semi-solid, or solid preparations intended for administration to the nasal cavities to obtain a systemic or local effect (Types of aqueous solutions)

A

Nasal preparation

69
Q

Used to wash, bathe, cleanse surgical wounds, incisions, & body tissues (Types of aqueous solutions)

A

Irrigations

70
Q

Is a sterile, hypotonic, non-pyrogenic irrigating fluid or pharmaceutical aid entirely composed of sterile water for injection, USP

A

Sterile water for irrigation, USP

71
Q

Are thick, viscid, adhesive liquids made by dispersing gum in water, or extracting the mucilagenous principle from vegetable susbtances with water (Types of aqueous solutions)

A

Mucilage

72
Q

2 methods of mucilage preparation (ED)

A

Extraction, Dispersion

73
Q

A hydroalcoholic preparation of volatile oils and aromatic substances (Types of non-aqueous solutions)

A

Spirits/Essences

74
Q

Are alcoholic or hydroalcoholic solutions prepared from vegetable or chemical substances (Types of non-aqueous solutions)

A

Tinctures

75
Q

Are liquid preparations of vegetable drugs, containing alcohol as solvent or as preservative, or both (Types of non-aqueous solutions)

A

Fluid extracts

76
Q

Clear, pleasantly flavored, sweetened hydroalcoholic solutions intended for oral use (Types of non-aqueous solutions)

A

Elixirs

77
Q

A syrupy solution of pyroxylin in a mixture of ether and alcohol; often used as protectant (Types of non-aqueous solutions)

A

Collodions

78
Q

Solutions or mixture of various substances in oil, alcoholic solution of soap, or emulsions, intended for external application (Types of non-aqueous solutions)

A

Liniments

79
Q

Are fish liver oils diluted with edible vegetable oil or solution of the indicated vitamins or vitamin concentrate in fish liver oil (Types of non-aqueous solutions)

A

Oleovitamins

80
Q

Temporarily relieves throbbing, persistent toothache due to a cavity (Types of non-aqueous solutions)

A

Toothache drops

81
Q

Spirits contain not less than __________ alcohol

A

60%

82
Q

Example of spirit prepared using simple solution with maceration

A

Peppermint spirit

83
Q

Example of spirit prepared using solution

A

Spirit of ammonia

84
Q

Example of spirit prepared using chemical reaction

A

Ethyl nitrate spirit

85
Q

Whisky and brandy are prepared by __________

A

Distillation

86
Q

Compound orange spirit, camphor spirit, and compound cardamon spirit are prepared by __________

A

Simple solution

87
Q

Contains 48% to 54% alcohol from grapes

A

Brandy/Spiritus vini vitis

88
Q

Contains 47-53% alcohol from cereals

A

Whisky/Spiritus frumenti

89
Q

Tinctures contain __________ to __________ alcohol

A

15-18%

90
Q

2 methods of tincture preparation (MP)

A

Maceration (Process M), Percolation (Process P)

91
Q

The drug is soaked with the menstruum in a closed container (Methods of tincture preparation)

A

Maceration (Process M)

92
Q

The drug is dampened with the menstruum and allowed to stand for a short period before packing the percolator so that the drug may expand (Methods of tincture preparation)

A

Percolation (Process P)

93
Q

Example of tincture performed using maceration

A

Orange peel tincture

94
Q

Example of tincture performed using percolation

A

Belladonna tincture

95
Q

A tincture prepared by maceration; used as a protectant to toughen skin in treatment of bed sores, ulcers, cracked nipples, and fissures of the lips and anus

A

Compound benzoin tincture

96
Q

Tincture that is similar to thimerosal topical solution except that sodium chloride and sodium borate are absent from the tincture and the vehicle of the tincture is water, acetone and about 50% alcohol

A

Thimerosal tincture

97
Q

Tincture prepared by dissolving 2% iodine crystals and 2.4% sodium iodide; is a popular local anti-infective agent

A

Iodine tincture

98
Q

Are solutions that employ an aqueous vehicle

A

Topical solutions

99
Q

Are tinctures that employ an alcoholic vehicle

A

Topical tinctures

100
Q

A topical colorless solution that has a faint acetous odor and sweetish, astringent taste; used in dermatologic lotions, creams, and pastes

A

Aluminum acetate topical solution

101
Q

A topical solution used as an astringent wash and wet dressing

A

Aluminum subacetate topical solution

102
Q

A topical solution more soluble in cold water than in hot water; used as an astringent

A

Calcium hydroxide topical solution (Lime water)

103
Q

A solution that is a black viscous liquid having a characteristic naphthalene-like odor and a sharp burning taste; is a local anti-eczematic used in treatment of chronic skin conditions

A

Coal tar solution

104
Q

Is obtained as a byproduct during destructive distillation of bituminous coal

A

Tar

105
Q

A topical solution categorized as a local anti-infective for use topically on the skin and mucous membrane

A

Hydrogen peroxide topical solution

106
Q

A solution employed extensively as a broad spectrum antiseptic in clinical and veterinarian medicine

A

Chlorhexidine gluconate solution

107
Q

A topical solution that is a chemical complex of iodine with polyvinylpyrrolidone; used as a surgical scrub and nonirritating antiseptic solution

A

Povidone iodine topical solution

108
Q

A water soluble organic mercurial antibacterial agent used topically for its bacteriostatic and mild fungistatic properties

A

Thimerosal

109
Q

Are concentrated preparations of a vegetable or animal drug obtained by the removal of the active constituents of the respective drugs with suitable menstrua

A

Extracts

110
Q

Are drug products obtained by extracting animal vegetable drug with suitable solvent system

A

Extractive

111
Q

Involves soaking in solvent (Processes involved in making extractives)

A

Maceration

112
Q

Involves boiling for 15 minutes (Processes involved in making extractives)

A

Decoction

113
Q

Involves soaking using a percolator (Processes involved in making extractives)

A

Percolation

114
Q

Involves using hot/cold water (Processes involved in making extractives)

A

Infusion

115
Q

Involves applying gentle heat (Processes involved in making extractives)

A

Digestion

116
Q

An extract that is too potent, too bitter-tasting, and unpalatable to be accepted by the patient (Example preparations prepared by extraction processes)

A

Fluid extract

117
Q

Concentrated preparations of vegetable or animal drugs obtained by the removal of the active constituents of the respective drugs with suitable solvent (Example preparations prepared by extraction processes)

A

Extracts

118
Q

Process that entails exhaustive percolation with an alcoholic or hydroalcoholic menstruum (Extraction processes)

A

Process A

119
Q

2 processes used in the preparation of fluid extract with boiling water as the menstruum (Example preparations prepared by extraction processes)

A

Process B and D

120
Q

Process that is intended to facilitate total drug extraction by collecting 1000 mL of percolate from each 1000 g of drug

A

Process C and E

121
Q

A licorice root fluid extract; used as a flavoring agent (Official preparations of extracts)

A

Glycyrrhiza fluid extract

122
Q

A Yerba santa fluid extract; used as a cathartic (Official preparations of extracts)

A

Eriodictyon fluid extract

123
Q

A Rhamnus purshiana fluid extract (Official preparations of extracts)

A

Cascara sagrada fluid extract; Aromatic Cascara sagrada fluid extract

124
Q

Also known as fluid extratum sennae (Official preparations of extracts)

A

Senna fluid extract

125
Q

20 mL of the solvent system is remained, removing all or most of the menstruum (Forms of extracts)

A

Syrupy/Semiliquid

126
Q

Plastic consistency; nearly all solvent (menstruum) has evaporated (Forms of extracts)

A

Pilular/Plastic consistency

127
Q

Dry extract by removal of all menstruum (Forms of extracts)

A

Powdered extract

128
Q

Elixirs contain __________ to __________ alcohol

A

5-40%

129
Q

2 types of elixirs (MN)

A

Medicated, Non-medicated

130
Q

Includes antihistaminic elixirs, sedative and hypnotic elixirs, and expectorants (Types of elixirs)

A

Medicated elixirs

131
Q

Used as solvents or vehicles for the preparation of medicated elixirs (Types of elixirs)

A

Non-medicated elixirs

132
Q

Elixir used in the symptomatic relief of certain allergic disorders (Examples of elixirs)

A

Antihistamine elixirs

133
Q

Elixirs that are sedative and hypnotic agents used to produce various degrees of a central system depression (Examples of elixirs)

A

Barbiturate

134
Q

Elixirs formulated to contain 0.4% of phenobarbital (Examples of elixirs)

A

Phenobarbital elixir

135
Q

Long acting barbiturate duration is __________ to __________ hours

A

4-6 hours

136
Q

Elixir that contains 4.5-5.25 mg of digoxin per 100 mL of elixir; obtained from the leaves of Digitalis lanata (Examples of elixirs)

A

Digoxin elixir

137
Q

Obtained from the action of H2SO4 and HNO3 on cotton; also known as nitrocellulose, cellulose nitrate, flash paper, and gun cotton

A

Pyroxylin

138
Q

2 types of collodions (FN)

A

Flexible, Non-flexible

139
Q

Used as a surgical dressing or to hold dressings in place (Types of collodions)

A

Flexible collodion

140
Q

Used in theatrical make-up (Types of collodions)

A

Non-flexible collodion

141
Q

Liniments are applied with rubbing to the affected areas and that is why they were once called __________

A

Embrocations

142
Q

2 types of liniments (OA)

A

Oleaginous, Alcoholic

143
Q

Applied to the skin with friction and rubbing; the oil and soap base provides for ease of application and massage (Types of liniments)

A

Oleaginous liniments

144
Q

Intended generally for their rubefacient, counterirritant, mildly astringent, and penetrating effects (Types of liniments)

A

Alcoholic liniments

145
Q

A variety of medicinal substances that are employed topically in the oral cavity

A

Dental oral solution

146
Q

Are liquid preparations for oral administration containing one or more substances with or without flavoring, sweetening or coloring agents dissolved in water or co-solvent water mixtures

A

Oral solutions

147
Q

Are solutions used for the treatment of patients with mild volume depletion of about 5-10% of their body weight (Examples of oral solutions)

A

Oral rehydration solutions (ORS)

148
Q

Are solutions that serve as an alternative method to prepare the GIT and requires less time and dietary restriction and obviates cleansing enemas (Examples of oral solutions)

A

Oral colonic lavage solution

149
Q

An oral laxative and cleansing enema administered around 2-4 hours prior to procedure (Examples of oral solutions)

A

Magnesium citrate oral solution (Citrate of magnesia)

150
Q

Contains 100 mg of sodium citrate and 67 mg of citric acid in each milliliter of aqueous solution (Examples of oral solutions)

A

Sodium citrate & citric acid oral solution

151
Q

Aromatic waters (Aqueous or nonaqueous)

A

Aqueous

152
Q

Syrups (Aqueous or nonaqueous)

A

Aqueous

153
Q

Douche (Aqueous or nonaqueous)

A

Aqueous

154
Q

Enemas (Aqueous or nonaqueous)

A

Aqueous

155
Q

Mouthwash (Aqueous or nonaqueous)

A

Aqueous

156
Q

Gargles (Aqueous or nonaqueous)

A

Aqueous

157
Q

Juices (Aqueous or nonaqueous)

A

Aqueous

158
Q

Otic/aural preparations (Aqueous or nonaqueous)

A

Aqueous

159
Q

Nasal preparations (Aqueous or nonaqueous)

A

Aqueous

160
Q

Irrigations (Aqueous or nonaqueous)

A

Aqueous

161
Q

Mucilage (Aqueous or nonaqueous)

A

Aqueous

162
Q

Spirits (Aqueous or nonaqueous)

A

Nonaqueous

163
Q

Tinctures (Aqueous or nonaqueous)

A

Nonaqueous

164
Q

Fluid extract (Aqueous or nonaqueous)

A

Nonaqueous

165
Q

Elixirs (Aqueous or nonaqueous)

A

Nonaqueous

166
Q

Collodions (Aqueous or nonaqueous)

A

Nonaqueous

167
Q

Liniments (Aqueous or nonaqueous)

A

Nonaqueous

168
Q

Oleovitamins (Aqueous or nonaqueous)

A

Nonaqueous

169
Q

Toothache drops (Aqueous or nonaqueous)

A

Nonaqueous

PH 107 - Pharmaceutical Dosage Forms, Drug Delivery Systems, and Medical Devices (Lec.) (15 decks)

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