Micturition Disorders Flashcards

1
Q

What nerve is responsible for PSNS innervation of the bladder, when activated causes urination?

A

Pelvic nerve

-also carries sensory information from the bladder wall)

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2
Q

What nerve is responsible for SNS innervation o the bladder and when activated causes bladder relaxation?

A

Hypogastric nerve

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3
Q

What nerve carries somatic motor fibers causing contraction of the external urethral sphincter?

A

Pudendal

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4
Q

Describe the urinary cycle??

A

Passive phase of filling
—> hypograstric activate B receptors allowing bladder stretching
—> activate a1-receptors of trigone and proximal urethra
Blocks PSNS

Active phase (voiding)
—> Reflex: stretch receptors to pelvic nerve to spinal cord, brain stem, stimulate PSNS
—> contraction of bladder wall

—>pudendal nerve decrease urethral sphincter tone (can be over ridden at cerebrum)

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5
Q

Large distended bladder
Difficult to express

Is this UMN or LMN bladder??

A

UMN —> detrusor areflexia and sphincter hyperreflexia

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6
Q

Large bladder, easily expressed, constantly leaks

Is this a UMN or LMN bladder?

A

LMN

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7
Q

Rx for UMN bladder?

A

Baclofen (antispasmodic, acts as inhibitory neurotransmitter and skeletal muscle relaxant)

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8
Q

What is detrusor-sphincter reflex dyssynergia?

A

With initiation of detrusor contraction, the urethral sphincter spasms

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9
Q

Rx for detrusor-sphincter reflex dyssynergia?

A

A-adrenergic blockers (phenoxybenzamine, prazosin, and tamulosin)

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10
Q

What is dysautonomia??

A

Rare disease whete the autonomic system is damaged

Affecting all systems
Usually presents and GI disease (ileus and dilated GI)

Poor prognosis

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11
Q

What causes detrusor atony?

A

Overfill (obstruction)

Large flaccid bladder
Neurological exam in normal

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12
Q

What is the RX for detursor atony?

A

Manual expression of the bladder

-usually is not persistent

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13
Q

What is detrusor instability/detrusor hyperreflexia?

A

Detrusor contraction during storage OR

Low compliance of detrusor

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14
Q

Clinical signs associated with detrusor instability/detrusor hyperreflexia ??

A

Pollakiuria, stranguria, and dysuria

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15
Q

What is the RX for detrusor instability/ detrusor hyperreflexia ???

A

Anticholinergic. — oxybutynin, imipramine, or dicyclomine

Causes relaxation of bladder wall

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16
Q

What are the mechanisms that cause urinary incontinence?

A

Intravesicular pressure is greater than urethral pressure

Anatomic abnormalities

17
Q

What is the most common etiology of urinary incontience??

A

Urinary sphincter mechanism incompetence (SMI)

18
Q

What is the DDX for urinary incontinence?

A

Neurological dz - LMN

Anatomical dz

  • ectopic ureters
  • vaginal stricture
  • pelvic bladder
  • ureterocele
  • ureterovaginal fistula
19
Q

What diseases have an apparent incontinence, but is not actually incontinence??

A

Pollakiuria
PU/Pd
Behavioral issues

Young bitches with hooded vulva

20
Q

What is the signalment and usual presentation of urinary spinchter incompetence?

A

Spayed bitch
Incidence higher in large breed dogs

Soiled perineal coat, urine scale, anatomical corrected
No neuro deficits

21
Q

What is urethral tone dependent on?

A

Urethral length
Reproductive status
-estrogen effect (thinner mucosal wall)
-lower number of a1 receptors

22
Q

Why are spayed females more predisposed to urinary incontinence ?

A

Lack of estrogen —> decreased sensitivity of the smooth muscle to sympathetic stimulation

Urinary sphincter pressure pre-spay = 18cmH2O
Post spay = 10cmH2O

Type I smooth fibers (responsible for continence) decrease after OVH

23
Q

What are indications for urethral pressure profiles?

A

Urethral sphincter mechanism incompetence

Detrusor instability

Reflex dyssynergia

Neurogenic abnormalities

24
Q

What is the treatment for urinary incontinence?

A

Ephedrine/phenylpropanolamine —> a1 agonists

Estriol —> increased striated muscle

25
Q

What are some associated side effects to estriol therapy?

A
Anorexia 
Emesis 
Swelling of the vulva 
Mammary hyperplasia 
Attractiveness of males 
Metorrhagia
26
Q

When is estriol therapy contraindicated ?

A

Immature bitches with congenital USMI

27
Q

What non-drug therapies can be used to treat urinary incontinence?

A

Collagen implantation —> good outcome, procedure may need to be repeated over lifetime

Colposuspension and urethropexy -> currently accepted but has limited improvement and high complication rate

Transobturator vaginal tape inside out for treatment of urethral sphincter mechanism incompetence -> fairly good owner satisfaction and continence

28
Q

What would you expect to find on clinical exam of a dog with ectopic ureters?

A

Wet coat
Inflamed perineum
Excoriations

29
Q

How can ectopic ureters be diagnosed?

A

Contrast enhanced (excretory urogram) CT and cystoscopy

IVP and CT can have false postives

30
Q

What is the treatment of choice for ectopic ureters?

A

Cystoscopic laser ablation