Microbiology - Prions Flashcards
0
Q
Name four human prion diseases.
A
1 CJD
2 Kuru
3 Gerstmann-Straussler Scheinker disease
4 Fatal familial insomnia
1
Q
Fancy name for prion disease =
A
Transmissible Spongiform Encephalopathy(TSE)
2
Q
PrPc are believed to be involved in these mechanisms?
A
Cellular signaling processes or copper metabolism.
3
Q
What are the three etiologies believed to cause Transmissible Spongiform Encephalopathy?
A
1 Inherited - AD mutations in the Prp gene.
2 Infectious - Exogenous PrPsc inducing conformational changes.
3 Sporadic - spontaneous conversion and de novo mutations.
