Microbiology -chapter 8 - Neisseria

Question 0

What two species of Neisseria cause disease in humans?

Answer 0

1 Neisseria meningitides

2 Neisseria gonorrhoeae

Question 1

The only pathogenic gram-negative cocci is?

Answer 1

Neisseria

Question 2

Name five virulence factors of Neisseria meningitides?

Answer 2

1 Capsule - classified into different serogroups based on this capsule
2 Endotoxin(LPS) - causes hemorrhage and sepsis
3 IgA1 protease - cleaves IgA in half
4 Neisseria meningitides can extract iron from humans
5 Pili - allows for adherence to nasopharyngeal cells.

Question 3

what are the three common pathogenic serogroups of Neisseria meningitides?

Answer 3

A, B & C

Question 4

Two organisms that have an anti-body free window in infants(6months to 2 yrs) that cause disease in the pediatric group?

Answer 4

Neisseria meningitides and Hemophilus influenzae

Question 5

What is the classic clue of an invasive meningococcal infection by meningococcus(Neisseria meningitides)?

Answer 5

A petichial rash

Question 6

Bulging open anterior fontanelle in neonate?

Answer 6

Meningitis. Neisseria, E coli and Listeria

Question 7

Thayer-Martin VCN media. What does the V and the C and the N stand for? And what is this media used for?

Answer 7

This media is used to culture Neisseria bacterium.

V - vancomyosin(kills gram positives)
C - Colistin(kills gram negs except Neisseria)
N - Nystatin(eliminates fungi)

Question 8

Virulence factors of Neiseria gonorrhoeae?

Answer 8

1 Pili - allows for adherence and prevent phagocytosis
2 Outer membrane protein porins - promote invasion into epithelium
3 Opa proteins - results in opaque colonies, allows for adherence and invasion.

Question 9

Possible complications of gonococcus infection in men?

Answer 9

epididymitis, prostatitis and urethral strictures.

Question 10

Complications of gonococcal disease in woman?

Answer 10

PID, endometriosis, salpingitis, oophoritis

Question 11

Complications of PID?

Answer 11

1 Sterility
2 Ectopic pregnancy
3 Abscesses(fallopian tubes, ovaries or peritoneum)
4 Peritonitis
5 Peri Hepatitis(infection of the capsule that surrounds the liver)

Question 12

The five genera of the greater family Neisseriaceae?

Answer 12

1 Neisseria
2 Moraxella
3 Kingella
4 Acinetobacter
5 Oligella

Question 13

Two major diseases caused by Moraxella catarrhalis?

Answer 13

otitis media and upper respiratory infection in patients with COPD.

Question 14

Otitis media occurs in 80% of children by the age of three. WHat are the three most common organisms causing otitis media in these kids?

Answer 14

Streptococcus pneumoniae > H. Influenzae&raquo_space; Moraxella catarrhalis

Question 15

What are the HACEK organisms that cause endocarditis?

Answer 15

Haemophilus species
Actinobacillus species
Cardiobacterium species
Eikenella species
Kingella species