Microbiology - chapter 10 - Hospital aquired gram-negs

Question 0

Name four often highly resistant gram-negative bacteria

Answer 0

1 Pseudomonas
2 Acinetobacter
3 Stenotrophomonas
4 Burkholderia

Question 1

What are the four W’s?

Answer 1

1 Wind - pneumonia, often associated with ventilators.
2 Water - UTI, seen with catherterization.
3 Wound - broken skin is an invitation for infectious disease.
4 Wires - e.g. IV lines.

All four are common ways of spreading hospital aquired gram-neg infections.

Question 2

Two reasons for the clinical significance of Psudomonas?

Answer 2

1 Opportunistic - colonizes and infects sick & immunocompromized
2 Resistant to almost every antibiotic out there

Question 3

Pseudomonas pathomechanism?

Answer 3

Exotoxin A - which has the same mechanism of action as diptheria toxin(stops protein synthesis)

Question 4

Important Pseudomonas infections?

Answer 4

BE PSEUDO =

Burns
Endocarditis

Pneumonia
Sepsis
External malignant otitis media
UTI
Diabetic Osteomyelitis

Question 5

Patients with cystic fibrosis are at greatest risk for disease due to this pathogen?

Answer 5

Burkholderia cepacia - an environmental bacteria that can grow in water, soil, plants and animals.

Question 6

Three good ways of preventing hospital aquired infections are?

Answer 6

1 Good hand hygiene by healthcare practitioners.
2 Limited use of invasive devices.
3 Judicious use of antibiotics.