Microbiology Flashcards

1
Q

What is bacterial vaginosis?

A

Imbalance of normal flora

Replacement of normal flora with Gardnerella vaginalis and anaerobic bacteria

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2
Q

How is bacterial vaginosis treated?

A

Not treated unless pregnant

Metronidazole

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3
Q

What pathogen causes chlamydia?

A

Chlamydia trachomatis

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4
Q

Which serovars of chlamydia cause eye infection?

A

A B C

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5
Q

Which serovars of chlamydia cause genital infection?

A

D to K

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6
Q

How is chlamydia tested for?

A

NAATs and PCR from swab

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7
Q

How is chlamydia treated?

A

100mg doxycycline BD 7 days
or
1g azithro then 500mg for 2 days

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8
Q

What pathogen causes gonorrhoea?

A

Neisseria gonorrahoeae

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9
Q

How is gonorrhoea investigated?

A

NAATs and PCR
Microscopy
Culture

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10
Q

How is gonorrhoea treated?

A

Ceftriaxone IM

Oral azithromycin

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11
Q

In which STI is a test of cure recommended?

A

Gonorrhoea

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12
Q

Which pathogen causes syphilis?

A

Treponema pallidum

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13
Q

How is syphilis investigated?

A

PCR and blood test

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14
Q

What is a chancre?

A

Painless ulcer which appears in syphilis

Spontaneously resolves

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15
Q

Other than sexually, how can syphilis be transmitted?

A

Saliva

Physical contact

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16
Q

How is syphilis treated?

A

Penicillin

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17
Q

Which parasites cause pubic lice?

A

Phthirus pubis

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18
Q

Which STIs can cause urethritis?

A

Chlamydia and gonorrhoea

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19
Q

What should be suspected in tenesmus and rectal bleeding in MSM?

A
Lymphogranuloma venereum
(serovars L1-L3 of chlamydia)
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20
Q

Which antibiotic is given for prostatitis?

A

Ciprofloxacin

Trimethoprim if high risk of C Diff

21
Q

Which organisms may be found in normal vaginal flora?

A

Lactobacillus
Strep viridans
GBHS
Candida

22
Q

Which pathogens cause thrush?

A

Candida

23
Q

Give examples of predisposing factors for candida infection?

A

Recent antibiotic therapy
High oestrogen
Poorly controlled diabetes
Immunocompromise

24
Q

How does candida infection present?

A

Intensely itchy white vaginal discharge

25
Q

How is candida infection diagnosed?

A

Clinical diagnosis

26
Q

How is candida infection treated?

A

Topical clotrimazole

Oral fluconazole

27
Q

How is bacterial vaginosis tested for ?

A

Microscopically examined for clue cells

with clinical suspicion and raised pH

28
Q

How does bacterial prostatitis present?

A
UTI symptoms 
Lower abdo pain
Perineal pain
Penile pain
Tender prostate
29
Q

Which pathogens cause bacterial prostatitis?

A

E coli. and coliforms
Entercoccus
Gonorrhoea
Chlamydia

30
Q

How is bacterial prostatitis diagnosed?

A

Mid stream urine sample

Culture & sensitivity

31
Q

Which samples are sent to be tested for chlamydia and gonorrhoea?

A

Male - first pass urine
Female - vulvovaginal swab
Rectal and throat swabs
Eye swabs

32
Q

What are the advantages of PCR and NAATs?

A

Less invasive
More sensitive
Positive with dead organisms
Quicker

33
Q

What are the disadvantages of PCR and NAATs?

A

Can’t test antibiotic sensitivities

Have to wait 5 weeks for test of cure

34
Q

Which virus causes genital warts?

A

HPV 6 & 11

35
Q

How are genital warts treated?

A

Cryotherapy

Podophyllotoxin cream/lotion

36
Q

What causes genital herpes?

A

HSV 1 and 2

37
Q

How is genital herpes spread?

A

Genital - genital

Genital - oropharyngeal

38
Q

Where does HSV replicate?

A

Dermis and epidermis then into nerve endings

39
Q

Where does HSV migrate to after the dermis?

A

Sacral root ganglion and “hides” from immune system

40
Q

How do genital herpes present?

A

Painful

Multiple small vesicles easily de-roofed

41
Q

How is active herpes tested for?

A

Swab taken of de-roofed blister for PCR test

42
Q

How is genital herpes treated?

A

Aciclovir

Pain relief

43
Q

What is trichomonas vaginalis?

A

Single celled parasite

44
Q

What symptoms does trichomonas vaginalis cause?

A

Vaginal discharge and irritation

Urethritis in males

45
Q

How is trichomonas vaginalis tested for?

A

High vaginal swab for microscopy

46
Q

How is trichomonas vaginalis treated?

A

Oral metronidazole

47
Q

What causes pubic lice?

A

Pthirus pubis

48
Q

How is pubic lice treated?

A

Malathion lotion