HIV

Question 1

What is HIV?

Answer 1

Single stranded retrovirus which infects and replicates in CD4 cells

Question 2

What codes single stranded HIV into double stranded DNA?

Answer 2

Reverse transcriptase

Question 3

Which enzyme is involved in incorporating single stranded HIV RNA into DNA?

Answer 3

Integrase

Question 4

How does the very early stage of HIV infection present?

Answer 4

Flu-like symptoms

seroconversion illness

Question 5

How does HIV present after the latent phase?

Answer 5

Weight loss
High temp
Diarrhoea
Freq opportunistic infection

Question 6

How is HIV managed?

Answer 6

Anti-retroviral therapy

Question 7

How is HAART therapy given?

Answer 7

Combination of 3 drugs from at least 2 classes

Question 8

Which anti-retrovirals increase MI risk?

Answer 8

Abacavir
Lopinavir
Maraviroc

Question 9

What are the main side effects of tenofovir?

Answer 9

Osteomalacia
Renal toxicity
Drowsy

Question 10

Which anti-retroviral is most likely to cause SJ syndrome?

Answer 10

Abacavir

Nevirapine

Question 11

Which anti-retroviral causes anaemia?

Answer 11

Zidovudine

Question 12

Which anti-retroviral causes psychosis and affects mood?

Answer 12

Efavarinez

Question 13

Which people should not be given tenofovir?

Answer 13

Shift workers
Night shift
Long haul drivers

Question 14

What cover needs to be given if patient comes off efavienz?

Answer 14

Protease inhibitor

Question 15

Vaginal delivery cannot be used in any pregnancy where the mother is HIV pos
true/false

Answer 15

False - its fine if the viral load is undetectable

Question 16

What drugs must be given to the infant after delivery from an HIV positive mother?

Answer 16

4 weeks PEP

Question 17

Which criteria must be met to be eligible for PrEP?

Answer 17

> 16
HIV neg
Commit to 3 monthly follow up
Resident in Scotland

Question 18

What would make a patient a high risk for HIV?

Answer 18

HIV+ partner with detectable viral load
MSM or transwoman
UPAI >2 partners in last 12 months
OR
Confirmed bacterial rectal STI in last 12 months

Question 19

How long is the allowed time between exposure and post-exposure prophylaxis?

Answer 19

72 hours