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PBD II Exam 2 - Micro Made Easy > Micro - Gram Negative Bacteria VII > Flashcards

Micro - Gram Negative Bacteria VII Flashcards

1
Q

gram negative obligate intracellular parasites

A

chlamydia - needs to steal ATP

rickettsia - can oxidize certain molecules to ATP

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2
Q

how to culture chlamydia and rickettsia

A

usually into embryo yolk sac

bc they can’t make ATP

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3
Q

chlamydia

A

gram negative
-no peptidoglycan layer and no muramic acid

likes columnar epithelial cells
-conjunctivits, cervicitis, pneumonia

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4
Q

chlamydia life cycle

A

elementary body (EB) - does not divide

  • attaches and enters columnar epithelial cells
  • inhibits phagosome-lysosome fusion and grows
initial body (reticulate body) - EB RNA increase and split by binary fission
-some back to EB - released from cell
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5
Q

species of chlamydia

A

trachomatis - eyes, genitals lungs

psittaci and pneumonia - lungs

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6
Q

chlamydia trachomatis

A

eyes and genitals

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7
Q

trachoma

A

chronic conjunctivitis

-from chlamydia trachomatis

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8
Q

most common cause of preventable blindness in world

A

trachoma

-native americans frequently infected

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9
Q

most common STD in US

A

chlamydia trachomatis

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10
Q

inclusion conjunctivitis

A

babies delivered in birth canals with chlamydia trachomatis

-purulent yellow discharge and swelling of eyelids 5-14 days after birth

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11
Q

diagnosis of chlamydia trachomatis

A

basophilic intracytoplasmic inclusion bodies

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12
Q

4-11 weeks old - upper respiratory symptoms followed by rapid breathing, cough, and resp distress

A

infant pneumonia caused by chlamydia trachomatis

Dx - confirmed by presence of anti-chlamydia IgM Abs

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13
Q

most common cause of urethritis

A

non-gonnococcal
-chlamydia trachomatis and ureaplasma urealyticum

second cause - neisseria gonorrhea

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14
Q

diagnosis for gonorrhea and chlamydia

A

nucleic acid amplification test

-PCR

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15
Q

PID

A

caused by both chlamydia trachomatis and neisseria gonorrhea

PD shuffle
chandelier sign

can lead to infertility, ectopic pregnancy, and chronic pelvic pain

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16
Q

unilateral scrotal swelling, tenderness, pain, with fever

A

chlamydial epididymitis

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17
Q

reiters syndrome

A

inflammatory arthritis of large joints
-young men - aged 20-40

caused by chlamydia trochamitis

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18
Q

fitz-hugh-curtis syndrome

A

infection of liver capsule with Sx of RUQ pain in men and women

-either cylamydia or gonoccocal infection

19
Q

lymphogranuloma venereum

A

caused by chlamydia trachomatis

  • painless bump on genitals that heals
  • migrate to regional nodes - tender and may break open
20
Q

psittacosis

A

caused by chlamydia psittaci
-common with bird breeders, vets, pet shop workers, poultry slaughterhouse workers

atypical pneumonia

21
Q

atypical pneumonia in bird handler

A

chlamydia psittaci

-psittacosis

22
Q

atypical pneumonia

A

viruses
mycobacterium pneumoniae
chlamydophila

23
Q

TWAR

A

species of chlamydophila pneumonia

  • causes atypical pneumonia
  • original isolation in taiwan
24
Q

small, non-motile, gram negative rod

A

rickettsia
-obligate intracellular parasite

requires arthropod vector

25
Q

tropism for endothelial cells

A

rickettsia

26
Q

Weil felix test

A

uses proteus vulgaris antigens to confirm rickettsial diagnosis

Ox-2, Ox-19, Ox-K

27
Q

rockettsia rockettsii

A

rocky mountain spotted fever
-tick bite

fever, conjunctival redness, headache, rash wrists and ankles to soles and palms then to trunk

most in south east US
-often resolves - can result in death

28
Q

fever, conjunctival redness, headache, rash on soles of feet and palms

A

rocky mountain spotted fever

-positive Ox-2 and Ox-19

29
Q

rickettsialpox

A

caused by rickettsia akaria
-transmitted via mites

initial localized skin bump turns to blister

  • fever and headache develop
  • vesicles appear all over body
30
Q

epidemic typhus

A

caused by rickettsial prowazekii
-positive Ox-19

-flying squirrel reservoir

abrupt fever, headache

  • small pink macules on upper trunk - then entire body
  • spares palms, soles, and face
31
Q

epidemic

A

sudden onset and rapid spread of infection

32
Q

endemic

A

infection existing constantly throughout population

33
Q

brill-zinsser disease

A

rickettsia prowazekii breaks out of latent state
-no skin rash**

diagnosis - rise in IgG for ricketsia prowazekii

IgM - occurs in primary infection

34
Q

endemic typhus

A

rickettsia typhi

  • flea born
  • fever, headache, flat bumpy rash develops
35
Q

tsutsugamushi fever

A

caused by rickettsia tsutsugamushi

-asian and southwest pacific

spread by chiggers (larvae) of mites

  • high fever, headache, scab at original bite site
  • flat bumpy rash develops
36
Q

traveler returns from sub-saharan africa with unexplained fever

A

rickettsia africae

37
Q

trench fever

A

caused by bartonella quintana

-not an obligate intracellular organism

  • high fever, rash, headache, severe back and leg pain
  • recover - then relapse 5 days later
  • multiple relapses
38
Q

high fever, rash, headache, severe back and leg pain

-recover, then relapse five days later

A

trench fever

-bartonella quintana

39
Q

cat-scratch disease

A

bartonella henselae

  • follows cat scratch of bite
  • low grade fever and malaise
40
Q

Q fever

A

coxiella burnetti

no endospore form

  • resistant to heat and drying
  • extracellular existence - outside host cell
  • non-arthropod transmission
  • mild pneumonia may develop
  • no rash

abrupt fever and soaking sweats with pneumonia

41
Q

cylamydia serotypes

A

A,B,C - trachoma - scarring inside eyelid

D-K - inclusion conjunctivitis, nongonococcal urethritis, PID

42
Q

diagnosis of urethritis

A

PCR of urethral swap or urine sample

43
Q

positive Ox-K

A

rickettsia tsutsugumashi

44
Q

positive Ox-19

A

rickettsia prowazekii or rickettsia typhi

PBD II Exam 2 - Micro Made Easy (21 decks)

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