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Step 1 Clues > micro drill sheet part 3 > Flashcards

micro drill sheet part 3 Flashcards

1
Q

WAS

A

Thrombocytopenia
IL-4, Eczema, 􏱶 IgM

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2
Q

SCID

A

􏱷 Adenosine deaminase deficiency, T>B,
frameshift/nonsense mutation,
􏱸 bacterial & fungal infx

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3
Q

CVID:Common variable immunodeficiency

A

Tyrosine kinase deficiency, late-onset, frameshift/
missense mutation

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4
Q

HIV (HTLV-l)

A

Effects CD-4 rich tissues (brain, testicles,
cervix, rectum, blood vessels), T>B

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5
Q

Job Syndrome

A

red-headed female,
tyrosine kinase deficiency

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6
Q

B-cell def

A

􏰀 Bruton’s Agammaglobulinemia - Tyrosine kinase deficiency
􏰀 Leukemia
􏰀 Lymphomas
􏰀 See above for those with T-cell overlap

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7
Q

DiGeorge’s

A

T-cell
hypocalcemia,
problem with 3rd and 4th pharyngeal pouches,
deletion of chromosome 22
cardio facial malformation

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8
Q

CD4 def

A

HIV

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9
Q

Chemical Uncouplers

A

􏰀 DNP
􏰀 Free Fatty Acids
􏰀 Aspirin

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10
Q

ETC complex 1 poison

A

Sodium amytal, Rotenone

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11
Q

Complex 2 poison

A

Malonate

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12
Q

complex 3 poison

A

Antimycin

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13
Q

complex 4

A

Cyanide
CO
chloramphenicol

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14
Q

complex 5

A

Oligomycin

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15
Q

Pyruvate
Amino acid

A

Gly, Ala, Ser

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15
Q

Acetyl CoA

A

Phe, Iso, Thr, Tyr, Lys, Leu

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16
Q

alpha-KetoG

A

Glu, Gln

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17
Q

Succinyl CoA

A

Phe, Ttp, Tyr

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18
Q

Fumerate

A

Pro

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19
Q

Asp, Asn

A

Oxaloacetate

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20
Q

PKU def

A

Phenylalanine hydroxylase deficiency, needed to make tyrosine, leads to a lack of Dopamine, Epi and Norepi, melanin

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21
Q

Maple Syrup Urine Disease

A

􏱷 deficiency in branched amino acids (Iso, Leu, Val), defective transport in the kidneys

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22
Q

Cystinuria

A

Cystathionine synthase deficiency;
cysteine, ornithine, lysine, and arginine; end up in urine, stones

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23
Q

O-bonds aa

A

Ser, Thr, Trp

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24
Q

N-bond aa

A

Asp, Gln

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25
Q

acidic aa

A

Asp
Glu

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26
Q

Basic aa

A

Arg
Lys

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27
Q

Ketogenic
Ketones KiLL

A

Lys,
Leu

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28
Q

gluco-ketogenic

A

Phe
Iso
Thr
Trp

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29
Q

Essential aa

A

PVT
TIM
HALL

Phe def=Tyr essential
Met def=Cys

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30
Q

Trypsin cuts right of

A

Arg
Lys

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31
Q

Chymotrpsin cut right of

A

phe
tyr
trp

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32
Q

Elastase cuts right of

A

gly
ser
ala

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33
Q

mercaptoethanol cuts right of

A

Met
cys

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34
Q

aminopeptidase cuts

A

amino terminal

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35
Q

carboxypeptidase cut left of

A

carboxy terminal

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36
Q

cyanobromid cut left of

A

met

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37
Q

cAMP

A

Sympathetic, catabolic, CRH

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38
Q

cGMP

A

Parasympathetic, anabolic

39
Q

2nd msg for Smooth muscle contraction by horm/NT. All hypothalamic hormones (except CRH)

A

IP3/DAG

40
Q

Smooth muscle contraction by distention

A

􏰀 Ca-Calmodulin

40
Q

2nd msg 4 Insulin and all growth factors

A

Tyrosine Kinase

40
Q

Nitrogen Oxide

A

Nitrates
Viagra
ANP
LPS: lipopolysaccharide

40
Q

co-factor for Dehydrogenase

A

TPP————— Thiamin (B1)
􏰀 Lipoic Acid. - B4
􏰀 CoA————-Pantothenic Acid (B5)
􏰀 FAD————- Riboflavin (B2)
􏰀 NAD————Niacin (B3)

41
Q

X-linked Recessive

A

Burton’ s Agammaglobulinemia
􏰀 CGD (NADPH Oxidase deficiency)
Duchene’s Muscular Dystrophy
􏰀 Color Blindness
􏰀 Hemophilia
􏰀 G6PD
􏰀 Lesch-Nyhan

􏰀 Fabry’s
􏰀 Hunter’s

42
Q

X-lined Dominant

A

􏰀 Rett Syndrome
􏰀 Vitamin D-resistant Rickets
􏰀 Pyruvate DH deficiency
Pseudohypoparathyroidism

43
Q

Nephrotic Patterns of Vasculitis
inflammation and clot

A

􏰀 Renal Artery Stenosis ——-Clot in front of renal artery
􏰀 Renal Failure ——– Clot off entire renal artery
􏰀 GN ——- Inflamed glomeruli

44
Q

Nephrotic Patterns of Vasculitis
inflammation and clot

A

􏰀 Papillary Necrosis ——– Clot in papilla
􏰀 Interstitial Nephritis ———- Clot of medulla
􏰀 Focal Segmental GN ———– Clot off pieces of nephron
􏰀 Rapidly Progressive GN ——— Clot off lots of nephrons

45
Q

MC Nephrotic Disease in Adults

A

􏱷 Membranous GN

46
Q

MC Renal Dz in Blacks/Hispanics

A

􏱷 Focal Segmental GN

47
Q

MC Renal Disease in HIV/IVDA

A

􏱷 Focal Segmental GN

48
Q

MC Renal Mass

A

􏱷 Cyst

49
Q

MC Malignant Renal tumor in adults

A

Adenocarcinoma

50
Q

MC Malignant Renal tumor in kids

A

􏱷 Wilm’s tumor

51
Q

MCC of Rapidly Progressive GN
crescent Formations

A

􏱷 Goodpasture’s

52
Q

MC Nephrotic Disease in kids
2 weeks post URI

A

􏱷 Minimal Change Disease

53
Q

Thrombolytic and Rescues
tPA and streptokinase

A

Aminocaproic acid

54
Q

Thrombolytic and Rescues warfarin

A

vit K

55
Q

Thrombolytic and Rescues Heparin

A

protamine sulfate

56
Q

Thrombolytic and Rescues if active hemorrhage

A

FFP

57
Q

Pneumovax

A

Covers MC 23 strains
􏰀 Given at. 2,4 &6 months
􏰀 Given to anyone over 65 years old
􏰀 Anyone who is asplenic
􏰀 Anyone with end-organ damage (CF, RF, Nephrotic

58
Q

Rashes Associated with Cancer urticaria (hives)

A

any, but especially lymphoma

59
Q

Rashes Associated with Cancer Paget’s dz

A

Intraductal carcinoma

60
Q

Intraductal carcinoma seborrheic keratosis

A

Colon cancer (HIV is sudden 􏱸)

61
Q

Rashes Associated with Cancer Actinic keratosis

A

Squamous cell carcinoma of skin

62
Q

Rashes Associated with Cancer Dermatomyositis

A

Colon cancer

63
Q

Rashes Associated with acanthuses nigracans

A

Visceral CA & end organ damage

64
Q

Rashes Associated with erythema nodosum

A

Granulomatous (nonbacterial)

65
Q

Ab SLE

A

Smith
Double-stranded DNA
Cardiolipin

66
Q

Cardiolipin causes

A

activate vWF
systemic clotting
3
4

67
Q

Ab Drug Induced SLE

A

Histone

68
Q

Progressive Systemic Sclerosis

A

Topoisomerase

69
Q

Graves

A

TSH Receptor

70
Q

CREST

A

Centromere

71
Q

Goodpasture’s

A

Type 4 Collagen

72
Q

Primary Biliary Cirrhosis

A

Mitochondria

73
Q

Alopecia Areata

A

Hair follicle

74
Q

Rheumatoid Arthritis

A

IgG FC portion

75
Q

Multiple Sclerosis

A

Myelin Receptors

76
Q

Celiac Sprue

A

Gliaden/gluten

77
Q

Type I Diabetes

A

Islet cell receptor

78
Q

Vitiligo

A

Melanocyte

79
Q

Myasthenia Gravis

A

Acetylcholine receptor

80
Q

Mixed Connective Tissue Disease

A

Ribonuclear protein

81
Q

Pernicious anemia

A

Intrinsic factor

82
Q

Pemphigus vulgaris

A

Desmosome

83
Q

Bullous pemphigoid

A

Hemidesmosome

84
Q

Hashimoto’s

A

Thyroglobulin Microsomal

85
Q

Scleroderma

A

Smooth Muscle SCL-70

86
Q

Sjogren’s

A

Rho
La

87
Q

Wegener’s

A

Proteinase
c-ANCA

88
Q

Polyarteritis Nodosa

A

p-ANCA

89
Q

Idiopathic Thrombocytic Purpura

A

Glycoprotein IIb/IIIa

90
Q

Cancer Grading

A

􏱷 Severity of microscopic change

91
Q

Cancer Staging

A

􏱷 Degree of dissemination of tumor

Step 1 Clues (27 decks)

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