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Mercy CLS 2: Microbiology > MIC > Flashcards

MIC Flashcards

1
Q

ESBLs hydrolyze…

A
  • penicillins
  • cephalosporins
  • monobactams (aztreonam)
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2
Q

sensitive to clavulinic acid

A

ESBL
KPC

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3
Q

resistant to clavulinic acid

A

ampC
NDM-1

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4
Q

sensitive to EDTA

A

NDM-1

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5
Q

ampC hydrolyzes…

A
  • penicillins
  • cephalosporins
  • cephamycins (cefoxitin, cefotetan, cefmetazole)
  • monobactams (aztreonam)
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6
Q

NDM-1s hydrolyze…

A
  • penicillins
  • cephalosporins
  • cephamycins (cefoxitin, cefotetan, cefmetazole)
  • carbapenems
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7
Q

KPCs hydrolyze…

A
  • penicillins
  • cephalosporins
  • cephamycins (cefoxitin, cefotetan, cefmetazole)
  • carbapenems
  • monobactams (aztreonam)
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8
Q

BLase sensitive to cephamycins

A

ESBLs

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9
Q

BLase sensitive to monobactams (aztreonam)

A

NDM-1s

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9
Q

BLase sensitive to carbapenems

A

ESBLs
ampCs

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10
Q

BLase sensitive to cefepime (4th gen cephalosporin)

A

ampC

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11
Q

B-lactam family of antibiotics affected by BLases (5)

A

penicillins
cephalosporins
cephamycins
carbapenems
monobactams

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12
Q

test for carbapenemase

A

Modified carbapenem inactivation method

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13
Q

explain modified carbapenem inactivation method

A
  • 10-μg meropenem (MEM) disk is incubated for 2 h in a suspension of a carbapenemase-producing microorganism
  • Carbapenem in the disk is degraded by the carbapenemase
  • Disk is removed from the suspension and placed onto a Mueller-Hinton agar (MHA) plate seeded with a suspension of a carbapenem-susceptible indicator organism (E. coli ATCC 25922)
  • Following overnight incubation, the zone of inhibition is measured to determine whether the carbapenem had been hydrolyzed (growth of the indicator organism close to the disk), or is still active (a large zone of inhibition around the disk)
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14
Q

KPC/CRE inhibited by…

A

clavulinic acid and tazobactam

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15
Q

anaerobes intrinsically resistant to…

A

aminoglycosides

16
Q

E. faecium intrinsically resistant to…

16
Q

GNs intrinsically resistant to…

A

vancomycin

16
Q

GPs intrinsically resistant to…

17
Q

Leuconostoc, Pediococcus and Lactobacillus intrinsically resistant to…

A

vancomycin

18
Q

Proteus, Providencia and Neissseria intrinsically resistant to…

A

polymyxins

19
Q

P. aeruginosa intrinsically resistant to…

A
  • penicillin
  • SXT
  • tetracycline
20
Q

Proteus intrinsically resistant to…

A
  • nitrofurantoin
  • tetracycline
21
Q

S. maltophilia intrinsically resistant to…

22
Q

inducible clindamycin resistance gene

23
Q

non-Enterobacterales with carbapenemase

A

Acinetobacter
Pseudomonas

24
Q

cefoxitin + oxacillin

A

synergisic activity

25
Q

3 types of gene transfer

A

transformation
conjugation
transduction

26
Q

tedizolid not reported on E. ——–

Mercy CLS 2: Microbiology (16 decks)

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