metronidazole Flashcards
what is it active against
Metronidazole is an antimicrobial drug with high activity against anaerobic bacteria and protozoa.
dose for Helicobacter pylori eradication [in combination with other drugs]
400 mg twice daily for 7 days for first- and second-line eradication therapy; 10 days for third-line eradication therapy.
dose for BV oral (2 options)
400–500 mg twice daily for 5–7 days, alternatively 2 g for 1 dose.
dose for BV vaginal gel
1 applicatorful once daily for 5 days, dose to be administered at night.
dose for PID
400 mg twice daily for 14 days.
dose for acute oral infections, adult
400 mg every 8 hours for 3–7 days.
cautions topical use
Avoid exposure to strong sunlight or UV light
5 warning labels
- do not drink alcohol
- space doses evenly; keep taking till finished
- take with or after food or a meal
- swallow whole, do not crush or chew
- take with full glass of water
take on empty stomach or with food?
with or after food
can you drink alcohol?
Do not drink alcohol while you’re taking metronidazole, including the 2 days after you finish
Alcohol potentially causes a disulfiram-like reaction when given with Metronidazole.
disulfuram + metronidazole interaction
Disulfiram increases the risk of acute psychoses when given with Metronidazole.
metronidazole + lithium
Metronidazole is predicted to increase the concentration of Lithium. Manufacturer advises avoid or adjust dose.
metronidazole + vit K antagonists
Metronidazole increases the anticoagulant effect of Warfarin. Manufacturer advises monitor INR and adjust dose.
nitrofurantoin, amiodarone, -platins, -taxels, phenytoin, vinka alkaloids, isoniazid interaction with metronidazole
peripheral neuropathy
