fosfomycin, fusidic acid, tedizolid, rifaximin

Question 1

common SE fosfomycin (5)

Answer 1

Abdominal pain; diarrhoea; headache; nausea; vomiting

Question 2

fosfomycin dose for acute uncomplicated lower UTI

Answer 2

mouth, using granules
3g for 1 dose

Question 3

spectrum of activity for fusidic acid

Answer 3

narrow spectrum
used for staph infections

Question 4

to avoid the development of resistance, fusidic acid should not be used for longer than …. days and local microbiology advice should be sought before using it in hospital

(topical)

Answer 4

10 days

Question 5

interaction: statins + fusidate

Answer 5

Fusidate has been reported to cause rhabdomyolysis when given with statins. Manufacturer advises avoid. Restart statin 7 days after last dose.

Question 6

fusidate systemic use - monitoring

Answer 6

LFT is high doses or prolonged therapy
also in pt with biliary tract obstruction, taking hepatotoxic meds, concurrent meds with similar excretion pathway

Question 7

is sodium fusidate the same thing as fusidic acid

Answer 7

yes may be prescribed as this

Question 8

what is rifaximin

Answer 8

rifamycin that is poorly absorbed from the gastro-intestinal tract, and, therefore, should not be used to treat systemic infections.

Question 9

indications for rifaximin - 2

Answer 9

Travellers’ diarrhoea that is not associated with fever, bloody diarrhoea, blood or leucocytes in the stool, or 8 or more unformed stools in the previous 24 hours

Reduction in recurrence of hepatic encephalopathy

Question 10

CI for rifaximin (1)

Answer 10

intestinal obstruction