fungal infection 2

Question 1

How is tinea capitis treated

Answer 1

systemically; additional topical application of antifungal may reduce transmission

adults and children: Griseofulvin

if caused by T. tonsurans can use terbinafine unlicensed

Question 2

Pityaris versicolour 1st line

Answer 2

antifungal shampoo (such as ketoconazole) that you use on the affected skin and rinse off after a few minutes.
antifungal cream.

Question 3

Pityaris versicolour treatment if 1st line topical treatment has failed

Answer 3

itraconazole
alt fluconazole

Question 4

where does pityaris versicolour usually appear and what does it look like

Answer 4

• Patches usually appear on chest, upper back, upper arms, neck or tummy
  
  • May look scaly, sometimes itchy
  • White: patches usually pink, red, pale brown; may notice patches do not tan in sun
  • Black/brown: patches tend to be paler than surrounding skin

Question 5

what is this

Answer 5

pityaris versicolour

Question 6

name some triazole antifungals

Answer 6

fluconazole
voriconazole
itraconazole

Question 7

name some imidazole antifungals

Answer 7

clotrimazole, econazole, ketoconazole, tioconazole

Question 8

name the 2 polyene antifungals

Answer 8

Amphotoeriein B and nystatin

neither is absorbed when given by mouth

Question 9

why is fluconazole a good choice for candiduria

Answer 9

excreted largely unchanged in urine

Question 10

which one of the triazoles is less freq associated with hepatotoxicity

Answer 10

fluconazole

Question 11

this triazole antifungal achieved good penetration to CSF to treat fungal meningitis

Answer 11

fluconazole

Question 12

this triazole capsules needs acid environemnt in stomach for optimal absoprtion

Answer 12

itraconazole caps

Question 13

this triazole has been associated with liver damage

Answer 13

itraconazole
caution or avoid in pt with liver disease

Question 14

are echinocandins (-fungin) effective against fungal infections of CNS

Answer 14

NO

Question 15

flucytosine is used with this drug in a synergistic combination

Answer 15

amph-B

Question 16

for this antifungal, bone marrow depression can occur which limits its use esp in HIV +ve people

Answer 16

flucytosine

Question 17

flucysotine limitations to use

Answer 17

• risk of bone marrow depression, esp if HIV +ve
• weekly blood counts needed during prolonged therapy
• resistance can develop during therapy
• sensitivity testing eseential before and during treatment!

Question 18

why is sensitivity testing crucial during and before treatment with flucytosine

Answer 18

resistance can develop

Question 19

what is the drug of choice for trichopyton (dermatophyte) infections in children

Answer 19

griseofulvin

Question 20

this is the drug of choice for fungal nail infections and also used for ringworm infections where oral treatment considered appropriate

Answer 20

terbinafine