aminoglycosides

Question 1

this AG is active against Mycobacterium tuberculosis and is now almost entirely reserved for TB

Answer 1

streptomycin

Question 2

name 5

Answer 2

amikacin
gentamicin
neomycin
streptomycin
tobramycin

Question 3

which 3 are active against P. aeruginosa

Answer 3

amikacin
gentamicin
tobramycin

Question 4

why do they need to be given by injection for systemic infections

Answer 4

not absorbed from the gut (although there is a risk of absorption in IBD and liver failure)

Question 5

true or false. gentamicin is active against anaerobes

Answer 5

false

Question 6

true or false - gentamicin has poor activity against haemolytic streptococci and pneumococci

Answer 6

true

Question 7

when used for blind therapy of undiagnosed serious infections, why is gentamicin usually given with a penicillin or metronidazole (or both)??

Answer 7

bc it is inactive against anaerobes and poor activity against haemolytic strepto and pneumococci

Question 8

wherever possible, treatment with gentamicin should not exceed

Answer 8

7 days

Question 9

which one is too toxic for parenteral admin and thus can only be used for infections of skin or mucous membrane or to reduce bacterial population of colon prior to bowel surgery or in liver failure?

Answer 9

neomycin

Question 10

small amounts of neomycin can be absorbed from the gut in pt with hepatic failure and as these pt may also be uraemic, the following can occur

Answer 10

cumulation with resultant ototoxicity

Question 11

serum AG conc MUST be determined in the following (5)

Answer 11

elderly
obesity
CF
high doses
RI