lincosamides Flashcards

1
Q

what is the only lincosamide called

A

clindamycin

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2
Q

contraindications with systemic use

A

diarrhoea states

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3
Q

what to do if you develop diarrhoea on clindamycin

A

discontinue

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4
Q

3 common SE with oral use - clindamycin

A

diarrhoea (discontinue)
abx associated colitis
abdominal pain

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5
Q

a general common SE of clindamycin is

A

skin reactions

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6
Q

the following occurs more frequently with clindamycin, although it can occur with most abx

A

abx associated colitis

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7
Q

important advice re Dalacin cream & conception and contraception

A

with vaginal use, Dalacin cream damages latex condoms and diaphragms!

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8
Q

important advice to give to pt who have Dalacin cream being used vaginally

A

it damages latex condoms and diaphragms

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9
Q

can clindamycin be used systemically in pregnancy

A

limited data
caution in 1st trimester
not known to be harmful in 2nd and 3rd trimesters

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10
Q

monitoring requirements with systemic use

A

LFTs and RFTs if treatment exceeds 10 days

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11
Q

the following need to be monitored if treatment exceeds 10 days

A

LFTs and RFTs

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12
Q

monitoring requirements with systemic use in children

A

monitor liver and renal function in neonates (0-28d) and infants

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13
Q

patient and carer advice

A

Patients and their carers should be advised to discontinue and contact a doctor immediately if severe, prolonged or bloody diarrhoea develops.

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14
Q

can it be used in MRSA

A

yes

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15
Q

what is Dalacin cream indicated for and what the dose?

A

bacterial vaginosis
1 applicatorful once daily for 3-7 nights, at night

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16
Q

can you use in BF?

A

caution present in milk
monitor infants for effects on GI flora e.g. diarrhoea, candidiasis, rarely blood in stool indicating possible abx associated colitis

17
Q

capsules need to be taken with

A

full glass of water

18
Q

MOA

A

binding to the 50S ribosomal subunit of bacteria, preventing protein synthesis
bacteriostatic

19
Q

narrow or broad spectrum

A

broad