Metoclopramide

Question 1

Pharmacology and presentation of Metoclopramide?

Answer 1

10mg/2ml ampoule

Antiemetic that inhibits dopamine D2 and serotonin 5-HT3 receptors in the chemoreceptor trigger zone. Metoclopramide also promotes gut motility by inhibiting presynaptic and postsynaptic D2 receptors as well as presynaptic 5-HT4 receptors (smooth muscle).

Question 2

Indicators of Metoclopramide?

Answer 2

• Nausea/vomiting associated with: narcotic pain relief &/pr past Hx of migraine

Question 3

Contraindications of Metoclopramide?

Answer 3

• Hypersensitivity
• <16years
• GIT haemorrhage, obstruction or perforation

Question 4

Cautions of Metoclopramide?

Answer 4

• Undiagnosed abdominal pain

Question 5

Side Effects of Metoclopramide?

(4x head, mouth, heart & muscle)

Answer 5

• Drowsiness
• Lethargy
• Dry mouth
• Muscle Tremor
• Hypotension or hypertension
• Extrapyramidal reaction
• Lowers seizure threshold

Question 6

Dosing Regimes of Metoclopramide?

Answer 6

.

Question 7

Onset and duration of Metoclopramide?

Answer 7

• Onset = 1-3 min IV or 10-15 minutes IM
• Duration = 10-30 minutes IV or 1-2 hours IM