Aspirin

Question 1

Pharmacology and presentation of Aspirin?

Answer 1

300mg tablets.

An anti-platelet aggregator with analgesic, antipyretic and anti-inflammatory effects. Inhibits cyclooxygenase reducing the formation of prostaglandins and thromboxane.

Question 2

Indicators of Aspirin?

Answer 2

• ACS (To minimize platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombosis in acute coronary syndrome)

Question 3

Contraindications of Aspirin?

(HA SCAB)

Answer 3

• Hypersensitivity to aspirin/salicylates
• Acute febrile illness in pt’s <12 due to risk of renal impairment and Reye’s Syndrome (acute noninflammatory encephalopathy and liver failure)
• Suspected dissecting aortic aneurysm
• Chest pain associated with psychostimulant OD SBP >160
• Actively bleeding peptic ulcers
• Bleeding disorders

Question 4

Cautions of Aspirin?

Answer 4

• Peptic ulcers
• Anti-coagulated
• Asthma

Question 5

Side Effects of Aspirin?

Answer 5

• Hypersensitivity reactions
• Increased bleeding
• GI Bleeding, nausea, heartburn

Question 6

Dosing Regimes of Aspirin?

Answer 6

ACS
- 300mg Orally

Question 7

Onset and duration of Aspirin?

Answer 7

• Onset = ~10 minutes peaks around 15
• Duration = ~7 days (natural life of platelet)