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Prostate cancer > Metastic & refractory disease Second generation antiandrogens > Flashcards

Metastic & refractory disease Second generation antiandrogens Flashcards

1
Q

What drug used when 1st gen antiandrogens failed ?

A

Enzalutamide effective in mCRPC

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2
Q

MOA Enzalutamide

A
  • prevents AR translocating into cell nucleus
  • inhibit androgen signaling
  • effective 1st line option
  • viable 2nd line option - failed prior docetaxel chemo
    = improves overal survival
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3
Q

Adverse effects

A
  • fatigue
  • diarrhoe ‘
  • hot flushes
  • MS pain
  • hepatotoxicity = LFT elevation
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4
Q

Rare serious a/e

A

seizures

posterior reversivle encephalopathy syndrome

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5
Q

IS it an inhibitor / inducer

A
  • strong inducer + inhibitor CYP3A4
  • moderate inducer + inhibtor CYP2C9 + CYP2C19
  • monitor DDI
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Prostate cancer (16 decks)

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