chemotherapy Flashcards
1
Q
MOA and typeof drug Docetaxel
A
- antimicrotuble taxane
- improve survival mCRPC - 75mg/m2 q3w + prednisone BD
2
Q
what improves overall survival in hormone-sensitive PCa + metastic patients who are treatment naive ?
A
Docetaxel + ADT
3
Q
Common a/e docetaxel
A
- N
- alopecia
- BM suppression
- fluid retention
- peripheral neuropathy
4
Q
What metabolism does docetaxel undergo?
A
- hepatic metabolism therefore C/I hepatic impairment
5
Q
MOA and use of Cabazitaxel
A
- antimicrotubule taxane
- active in docetaxel-resistant cell lines
- low affinity p-glycoprotein efflux transporter
- dose 20mg/m2 q3w + prednisone 10mg/daily
6
Q
adverse effects cabazitaxel
A
- neutropenia
- neuropathy
- diarrhoea
7
Q
hypersentivity rxna cabazitaxel
A
- premedicate with
- antihistamine
- corticosteroids
H2 antagonist
8
Q
metabolism cabazitaxel
A
- extensive hepatic met therefore C/I hepatic dysfunction
